Product Information
Registration Status: ActiveNATACYN 5% STERILE OPHTHALMIC SUSPENSION is approved to be sold in Singapore with effective from 1991-09-12. It is marketed by NOVARTIS (SINGAPORE) PTE LTD, with the registration number of SIN06719P.
This product contains Natamycin 5% in the form of SOLUTION. It is approved for OPHTHALMIC use.
This product is manufactured by ALCON LABORATORIES INC in UNITED STATES.
It is a Prescription Only Medicine that can only be obtained from a doctor or a dentist, or a pharmacist with a prescription from a Singapore-registered doctor or dentist.
Description
Amphoteric macrolide antifungal antibiotic from Streptomyces natalensis or S. chattanoogensis. It is used for a variety of fungal infections, mainly topically. [PubChem]
Indication
For the treatment of fungal blepharitis, conjunctivitis, and keratitis caused by susceptible organisms including Fusarium solani keratitis.
Mechanism of Action
LIke other polyene antibiotics, Natamycin inhibits fungal growth by binding to sterols. Specifically, Natamycin binds to ergosterol in the plasma membrane, preventing ergosterol-dependent fusion of vacuoles, as well as membrane fusion and fission. This differs from the mechanism of most other polyene antibiotics, which tend to work by altering fungal membrane permeability instead.
Pharmacokinetics
- Absorption
- Systemic absorption should not be expected following topical administration, and as with other polyene antibiotics, absorption from the gastrointestinal tract is very poor.
- Distribution
- Metabolism
- Elimination
Active Ingredient/Synonyms
Natamicina | Natamycin | Natamycine | Natamycinum | Pimaracin | Pimaricin | Natamycin |
Source of information: Drugbank (External Link). Last updated on: 3rd July 18. *Trade Name used in the content below may not be the same as the HSA-registered product.