DISTOCIDE TABLET 600mg

Product Information

Registration Status: Active

DISTOCIDE TABLET 600mg is approved to be sold in Singapore with effective from 1992-06-02. It is marketed by ZYFAS MEDICAL CO, with the registration number of SIN06822P.

This product contains Praziquantel 600mg in the form of TABLET, FILM-COATED. It is approved for ORAL use.

This product is manufactured by SHIN POONG PHARMACEUTICAL CO LTD in KOREA, and in REPUBLIC OF.

It is a Prescription Only Medicine that can only be obtained from a doctor or a dentist, or a pharmacist with a prescription from a Singapore-registered doctor or dentist.

Praziquantel

Description

An anthelmintic used in most schistosome and many cestode infestations.

Indication

For the treatment of infections due to all species of schistosoma.

Mechanism of Action

Praziquantel works by causing severe spasms and paralysis of the worms' muscles. This paralysis is accompanied - and probably caused - by a rapid Ca 2+ influx inside the schistosome. Morphological alterations are another early effect of praziquantel. These morphological alterations are accompanied by an increased exposure of schistosome antigens at the parasite surface. The worms are then either completely destroyed in the intestine or passed in the stool. An interesting quirk of praziquantel is that it is relatively ineffective against juvenile schistosomes. While initially effective, effectiveness against schistosomes decreases until it reaches a minimum at 3-4 weeks. Effectiveness then increases again until it is once again fully effective at 6-7 weeks. Glutathione S-transferase (GST), an essential detoxification enzyme in parasitic helminths, is a major vaccine target and a drug target against schistosomiasis. Schistosome calcium ion channels are currently the only known target of praziquantel.

Pharmacokinetics

Absorption
Rapidly absorbed (80%)
Distribution
Metabolism
renal
Elimination

Active Ingredient/Synonyms

Praziquantel | Praziquantel |


Source of information: Drugbank (External Link). Last updated on: 3rd July 18. *Trade Name used in the content below may not be the same as the HSA-registered product.

References

  1. Health Science Authority of Singapore - Reclassified POM
  2. Drugbank