Product Information
Registration Status: ActivePROBENECID TABLET 500mg is approved to be sold in Singapore with effective from 1994-04-15. It is marketed by SUNWARD PHARMACEUTICAL PTE LTD, with the registration number of SIN07685P.
This product contains Probenecid 500mg in the form of TABLET. It is approved for ORAL use.
This product is manufactured by SUNWARD PHARMACEUTICAL PTE LTD in SINGAPORE.
It is a Prescription Only Medicine that can only be obtained from a doctor or a dentist, or a pharmacist with a prescription from a Singapore-registered doctor or dentist.
Description
The prototypical uricosuric agent. It inhibits the renal excretion of organic anions and reduces tubular reabsorption of urate. Probenecid has also been used to treat patients with renal impairment, and, because it reduces the renal tubular excretion of other drugs, has been used as an adjunct to antibacterial therapy. [PubChem]
Indication
For the reduction of serum uric acid concentrations in chronic gouty arthritis and tophaceous gout in patients with frequent disabling gout attacks. Has also been effectively used to promote uric acid excretion in hyperuricemia secondary to the administration of thiazide and related diuretics.
Mechanism of Action
Probenecid inhibits the tubular reabsorption of urate, thus increasing the urinary excretion of uric acid and decreasing serum urate levels. Probenecid may also reduce plasma binding of urate and inhibit renal secretion of uric acid at subtherapeutic concentrations. The mechanism by which probenecid inhibits renal tubular transport is not known, but the drug may inhibit transport enzymes that require a source of high energy phosphate bonds and/or nonspecifically interfere with substrate access to protein receptor sites on the kidney tubules.
Active Ingredient/Synonyms
4-((Dipropylamino)sulfonyl)benzoic acid | 4-(Di-N-propylsulfamoyl)benzoesaeure | 4-(N,N-Dipropylsulfamoyl)benzoesaeure | P-(Dipropylsulfamoyl)benzoic acid | Probenecid acid | Probenecida | Probenecide | Probenecidum | Probenecid |
Source of information: Drugbank (External Link). Last updated on: 3rd July 18. *Trade Name used in the content below may not be the same as the HSA-registered product.