Product Information
Registration Status: ActiveDESOWEN LOTION 0.05% is approved to be sold in Singapore with effective from 1996-02-13. It is marketed by GALDERMA SINGAPORE PTE LTD, with the registration number of SIN08572P.
This product contains Desonide 0.05% in the form of LOTION. It is approved for TOPICAL use.
This product is manufactured by LABORATOIRES GALDERMA in FRANCE.
It is a has been granted the exemption for supply without a presciption if it met certain criteria.
Description
A nonfluorinated corticosteroid anti-inflammatory agent used topically for dermatoses. [PubChem]
Indication
For the relief of the inflammatory and pruritic manifestations of corticosteroid responsive dermatose.
Mechanism of Action
Like other topical corticosteroids, desonide has anti-inflammatory, antipruritic and vasoconstrictive properties. The drug binds to cytosolic glucocorticoid receptors. This complex migrates to the nucleus and binds to genetic elements on the DNA. This activates and represses various genes. However corticosteroids are thought to act by the induction of phospholipase A2 inhibitory proteins, collectively called lipocortins. It is postulated that these proteins control the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes by inhibiting the release of their common precursor arachidonic acid. Arachidonic acid is released from membrane phospholipids by phospholipase A2.
Pharmacokinetics
- Absorption
- Topical corticosteroids can be absorbed from normal intact skin, inflammation and/or other disease processes in the skin may increase percutaneous absorption.
- Distribution
- Metabolism
- Elimination
Active Ingredient/Synonyms
11beta,21-Dihydroxy-16alpha,17-[(1-methylethylidene)bis(oxy)]pregna-1,4-diene-3,20-dione | 11beta,21-Dihydroxy-16alpha,17-isopropylidenedioxypregna-1,4-diene-3,20-dione | 11beta,21-Dihydroxy-16alpha,17alpha-isopropylidenedioxypregna-1,4-diene-3,20-dione | 16alpha-Hydroxyprednisole-16,17-acetonide | 16alpha-Hydroxyprednisolone-16alpha,17-acetonide | 16alpha,17alpha-Isopropylidenedioxyprednisolone | Desfluorotriamcinolone acetonide | Desonida | Desonidum | Desonide |
Source of information: Drugbank (External Link). Last updated on: 3rd July 18. *Trade Name used in the content below may not be the same as the HSA-registered product.