Product Information
Registration Status: ActiveALLUMAG M TABLET is approved to be sold in Singapore with effective from 1997-09-25. It is marketed by PHARMATECH RESOURCES (FE) PTE LTD, with the registration number of SIN09499P.
This product contains Aluminium Hydroxide 120mg, and Magnesium Trisilicate 250mg in the form of TABLET. It is approved for ORAL use.
This product is manufactured by BIOSIS PHARMACEUTICALS SDN BHD in MALAYSIA.
It is an Over-the-counter Medicine that can be freely obtained from any retailer
Description
Aluminum hydroxide is an inorganic salt used as an antacid. It is a basic compound that acts by neutralizing hydrochloric acid in gastric secretions. Subsequent increases in pH may inhibit the action of pepsin. An increase in bicarbonate ions and prostaglandins may also confer cytoprotective effects.
Indication
For relief of heartburn and acid indigestion.
Mechanism of Action
Aluminum hydroxide is a basic inorganic salt that acts by neutralizing hydrochloric acid in gastric secretions. Aluminum hydroxide is slowly solubilized in the stomach and reacts with hydrochloric acid to form aluminum chloride and water. It also inhibits the action of pepsin by increasing the pH and via adsorption. Cytoprotective effects may occur through increases in bicarbonate ion (HCO3-) and prostaglandins.
Pharmacokinetics
- Absorption
- Approximately 17-30% of the aluminum chloride formed is absorbed.
- Distribution
- Metabolism
- Not metabolized.
- Elimination
Active Ingredient/Synonyms
Aluminium hydroxide | Aluminium hydroxide gel, dried | Aluminium hydroxide, dried | Aluminum hydroxide gel, dried | Aluminum hydroxide, dried | Dried aluminium hydroxide | Dried aluminum hydroxide gel | Aluminum hydroxide |
Source of information: Drugbank (External Link). Last updated on: 3rd July 18. *Trade Name used in the content below may not be the same as the HSA-registered product.
Description
Magnesium trisilicate is an inorganic compound that is used as an antacid in the treatment of peptic ulcers.
Indication
For the treatment of peptic ulcers. Relieving indigestion and heartburn.
Mechanism of Action
The gelatinous silicon dioxide, formed by the reaction of magnesium trisilicate with gastric contents is said to protect ulcerated mucosal surfaces and favor healing.
Pharmacokinetics
- Absorption
- The hydrated silicon dioxide formed in the stomach and passes into the intestinal track where, silica can be partly absorbed.
- Distribution
- The hydrated silicon dioxide formed in the stomach and passes into the intestinal track.
- Metabolism
- Elimination
Clearance
Maximum magnesium clearance is directly proportional to creatinine clearance.
Toxicity
Adequate doses of magnesium trisilicate may cause diarrhea due to the action of soluble magnesium salts in the enteric tract. Approx 5% of the magnesium is absorbed.
Active Ingredient/Synonyms
Magnesium Trisilicate | Magnesium Trisilicate |
Source of information: Drugbank (External Link). Last updated on: 3rd July 18. *Trade Name used in the content below may not be the same as the HSA-registered product.