Product Information
Registration Status: ActiveCETROTIDE INJECTION 0.25mg is approved to be sold in Singapore with effective from 2000-10-07. It is marketed by MERCK PTE LTD, with the registration number of SIN11345P.
This product contains Cetrorelix 0.25mg in the form of INJECTION. It is approved for SUBCUTANEOUS use.
This product is manufactured by BAXTER ONCOLOGY GMBH in FRANCE,Abbott Biologicals B.V. (Water for Injection) in GERMANY, andPierre Fabre Medicament Production in NETHERLANDS.
It is a Prescription Only Medicine that can only be obtained from a doctor or a dentist, or a pharmacist with a prescription from a Singapore-registered doctor or dentist.
Description
Cetrorelix is a man-made hormone that blocks the effects of Gonadotropin Releasing Hormone (GnRH). GnRH controls another hormone that is called luteinizing hormone (LH), which is the hormone that starts ovulation during the menstrual cycle. When undergoing hormone treatment sometimes premature ovulation can occur, leading to eggs that are not ready for fertilization to be released. Cetrorelix does not allow the premature release of these eggs to occur.
Indication
For the inhibition of premature LH surges in women undergoing controlled ovarian stimulation
Mechanism of Action
Cetrorelix binds to the gonadotropin releasing hormone receptor and acts as a potent inhibitor of gonadotropin secretion. It competes with natural GnRH for binding to membrane receptors on pituitary cells and thus controls the release of LH and FSH in a dose-dependent manner.
Pharmacokinetics
- Absorption
- Rapidly absorbed following subcutaneous injection. The mean absolute bioavailability following subcutaneous administration to healthy female subjects is 85%.
- Distribution
- * 1.16 L/kg
- Metabolism
- In in vitro studies, cetrorelix was stable against phase I- and phase II-metabolism. Cetrorelix was transformed by peptidases, and the (1-4) peptide was the predominant metabolite.
- Elimination
Clearance
* 1.28 ml/min·kg [adult healthy female with 3 mg single SC administration]
Active Ingredient/Synonyms
Cetrorelixum | Cetrorelix |
Source of information: Drugbank (External Link). Last updated on: 3rd July 18. *Trade Name used in the content below may not be the same as the HSA-registered product.