ACTAL PLUS TABLET

Product Information

Registration Status: Active

ACTAL PLUS TABLET is approved to be sold in Singapore with effective from 1993-03-29. It is marketed by A. MENARINI SINGAPORE PTE LTD, with the registration number of SIN07376P.

This product contains Magnesium Hydroxide Powder 152mg ,Simethicone 25mg, and Sodium Polyhydroxyaluminium Monocarbonate Hexitol Complex 333mg 200mg in the form of TABLET. It is approved for ORAL use.

This product is manufactured by PHARMANIAGA MANUFACTURING BERHAD in MALAYSIA.

It is an Over-the-counter Medicine that can be freely obtained from any retailer

Magnesium Hydroxide Powder
Simethicone
Sodium Polyhydroxyaluminium Monocarbonate Hexitol Complex 333mg


Source of information: Drugbank (External Link). Last updated on: 3rd July 18. *Trade Name used in the content below may not be the same as the HSA-registered product.


Description

Simethicone is an orally administered antifoaming agent. It is mainly used to reduce gas from the gastrointestinal tract (GIT) in patients complaining from recurrent flatulence. Simethicone is a mixture of polydimethylsiloxane and hydrated silica gel. It exerts its action locally in the GIT, it is not absorbed into the blood stream. The main side effects of simethicone are GIT related including: mild diarrhea, nausea and vomiting.

Indication

1. To relieve pain and discomfort caused by excess gas in the intestine and stomach in cases such as flatulence and post operative gaseous distention. 2. It could be used also prior to an endoscopy to eliminate foam, gas and air from the gastrointestinal tract to reduce gas shadow which will result in better visualization.

Mechanism of Action

Decreases the surface tension of gas bubbles thereby disperses and prevents gas pockets in the GI system.

Pharmacokinetics

Absorption
Not absorbed following oral administration.
Distribution
Simethicone is pharmacologically inert and is not absorbed from the gastrointestinal tract.
Metabolism
The drug is not absorbed and it is excreted in the feces unchanged.
Elimination

Clearance

Excreted unchanged in feces.

Toxicity

LD50 (oral, rat): 4070 mg/Kg.

Active Ingredient/Synonyms

Simeticone | Simethicone |


Source of information: Drugbank (External Link). Last updated on: 3rd July 18. *Trade Name used in the content below may not be the same as the HSA-registered product.



Source of information: Drugbank (External Link). Last updated on: 3rd July 18. *Trade Name used in the content below may not be the same as the HSA-registered product.

References

  1. Health Science Authority of Singapore - Reclassified POM
  2. Drugbank