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ALUMAG PLUS TABLET

Product Information

Registration Status: Active

SIN03547P

ALUMAG PLUS TABLET is approved to be sold in Singapore with effective from 1989-06-06. It is marketed by BEACONS PHARMACEUTICALS PTE LTD, with the registration number of SIN03547P.

This product contains Aluminium Hydroxide 250mg,Magnesium Trisilicate 250mg, and Simethicone 30mg in the form of TABLET. It is approved for ORAL use.

This product is manufactured by BEACONS PHARMACEUTICALS PTE LTD in SINGAPORE.

It is an Over-the-counter Medicine that can be freely obtained from any retailer

Product Reference
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Description

Aluminum hydroxide is an inorganic salt used as an antacid. It is a basic compound that acts by neutralizing hydrochloric acid in gastric secretions. Subsequent increases in pH may inhibit the action of pepsin. An increase in bicarbonate ions and prostaglandins may also confer cytoprotective effects.

Indication

For relief of heartburn and acid indigestion.

Mechanism of Action

Aluminum hydroxide is a basic inorganic salt that acts by neutralizing hydrochloric acid in gastric secretions. Aluminum hydroxide is slowly solubilized in the stomach and reacts with hydrochloric acid to form aluminum chloride and water. It also inhibits the action of pepsin by increasing the pH and via adsorption. Cytoprotective effects may occur through increases in bicarbonate ion (HCO3-) and prostaglandins.

Pharmacokinetics

Absorption
Approximately 17-30% of the aluminum chloride formed is absorbed.
Distribution
Metabolism
Not metabolized.
Elimination

Active Ingredient/Synonyms

Aluminium hydroxide | Aluminium hydroxide gel, dried | Aluminium hydroxide, dried | Aluminum hydroxide gel, dried | Aluminum hydroxide, dried | Dried aluminium hydroxide | Dried aluminum hydroxide gel | Aluminum hydroxide |


Source of information: Drugbank (External Link). Last updated on: 3rd July 18. *Trade Name used in the content below may not be the same as the HSA-registered product.


Description

Magnesium trisilicate is an inorganic compound that is used as an antacid in the treatment of peptic ulcers.

Indication

For the treatment of peptic ulcers. Relieving indigestion and heartburn.

Mechanism of Action

The gelatinous silicon dioxide, formed by the reaction of magnesium trisilicate with gastric contents is said to protect ulcerated mucosal surfaces and favor healing.

Pharmacokinetics

Absorption
The hydrated silicon dioxide formed in the stomach and passes into the intestinal track where, silica can be partly absorbed.
Distribution
The hydrated silicon dioxide formed in the stomach and passes into the intestinal track.
Metabolism
Elimination

Clearance

Maximum magnesium clearance is directly proportional to creatinine clearance.

Toxicity

Adequate doses of magnesium trisilicate may cause diarrhea due to the action of soluble magnesium salts in the enteric tract. Approx 5% of the magnesium is absorbed.

Active Ingredient/Synonyms

Magnesium Trisilicate | Magnesium Trisilicate |


Source of information: Drugbank (External Link). Last updated on: 3rd July 18. *Trade Name used in the content below may not be the same as the HSA-registered product.


Description

Simethicone is an orally administered antifoaming agent. It is mainly used to reduce gas from the gastrointestinal tract (GIT) in patients complaining from recurrent flatulence. Simethicone is a mixture of polydimethylsiloxane and hydrated silica gel. It exerts its action locally in the GIT, it is not absorbed into the blood stream. The main side effects of simethicone are GIT related including: mild diarrhea, nausea and vomiting.

Indication

1. To relieve pain and discomfort caused by excess gas in the intestine and stomach in cases such as flatulence and post operative gaseous distention. 2. It could be used also prior to an endoscopy to eliminate foam, gas and air from the gastrointestinal tract to reduce gas shadow which will result in better visualization.

Mechanism of Action

Decreases the surface tension of gas bubbles thereby disperses and prevents gas pockets in the GI system.

Pharmacokinetics

Absorption
Not absorbed following oral administration.
Distribution
Simethicone is pharmacologically inert and is not absorbed from the gastrointestinal tract.
Metabolism
The drug is not absorbed and it is excreted in the feces unchanged.
Elimination

Clearance

Excreted unchanged in feces.

Toxicity

LD50 (oral, rat): 4070 mg/Kg.

Active Ingredient/Synonyms

Simeticone | Simethicone |


Source of information: Drugbank (External Link). Last updated on: 3rd July 18. *Trade Name used in the content below may not be the same as the HSA-registered product.

References

  1. Health Science Authority of Singapore - Reclassified POM
  2. Drugbank

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