Product Information
Registration Status: ActiveASCORBIC ACID INJECTION USP 500mg/5ml is approved to be sold in Singapore with effective from 1991-05-21. It is marketed by PHEBRA (SE ASIA) PTE LTD, with the registration number of SIN05858P.
This product contains Ascorbic Acid 500mg/5ml in the form of INJECTION. It is approved for INTRAVENOUS, INTRAMUSCULAR use.
This product is manufactured by Hospira Australia Pty Ltd in AUSTRALIA.
It is an Over-the-counter Medicine that can be freely obtained from any retailer
Description
A six carbon compound related to glucose. It is found naturally in citrus fruits and many vegetables. Ascorbic acid is an essential nutrient in human diets, and necessary to maintain connective tissue and bone. Its biologically active form, vitamin C, functions as a reducing agent and coenzyme in several metabolic pathways. Vitamin C is considered an antioxidant.
Indication
Used to treat vitamin C deficiency, scurvy, delayed wound and bone healing, urine acidification, and in general as an antioxidant. It has also been suggested to be an effective antiviral agent.
Mechanism of Action
In humans, an exogenous source of ascorbic acid is required for collagen formation and tissue repair by acting as a cofactor in the posttranslational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins. Ascorbic acid is reversibly oxidized to dehydroascorbic acid in the body. These two forms of the vitamin are believed to be important in oxidation-reduction reactions. The vitamin is involved in tyrosine metabolism, conversion of folic acid to folinic acid, carbohydrate metabolism, synthesis of lipids and proteins, iron metabolism, resistance to infections, and cellular respiration.
Pharmacokinetics
- Absorption
- 70% to 90%
- Distribution
- Metabolism
- Hepatic. Ascorbic acid is reversibly oxidised (by removal of the hydrogen from the enediol group of ascorbic acid) to dehydroascorbic acid. The two forms found in body fluids are physiologically active. Some ascorbic acid is metabolized to inactive compounds including ascorbic acid-2-sulfate and oxalic acid.
- Elimination
Active Ingredient/Synonyms
acide ascorbique | ácido ascórbico | acidum ascorbicum | acidum ascorbinicum | Ascorbate | Ascorbic Acid | Ascorbicap | Ascorbinsäure | L-(+)-ascorbic acid | L-Ascorbate | L-Ascorbic Acid | Vitamin C |
Source of information: Drugbank (External Link). Last updated on: 3rd July 18. *Trade Name used in the content below may not be the same as the HSA-registered product.