Product Information
Registration Status: ActiveSIN06735P
BENZYL BENZOATE APPLICATION BP 25% W/V is approved to be sold in Singapore with effective from 1991-12-13. It is marketed by ICM PHARMA PTE LTD, with the registration number of SIN06735P.
This product contains Benzyl Benzoate 25% w/v in the form of EMULSION. It is approved for TOPICAL use.
This product is manufactured by ICM PHARMA PTE LTD in SINGAPORE.
It is an Over-the-counter Medicine that can be freely obtained from any retailer
Product Reference
Important Note: For generic product, the SPC/PIL provided may not be brand specific.
{{/items}} {{^items}}Description
Benzyl benzoate is one of the older preparations used to treat scabies. Scabies is a skin infection caused by the mite sarcoptes scabiei. It is characterised by severe itching (particularly at night), red spots, and may lead to a secondary infection. Benzyl benzoate is lethal to this mite and so is useful in the treatment of scabies. It is also used to treat lice infestation of the head and body. Benzyl benzoate is not the treatment of choice for scabies due to its irritant properties.
Indication
Used to kill lice and the mites responsible for the skin condition scabies.
Mechanism of Action
Benzyl benzoate exerts toxic effects on the nervous system of the parasite, resulting in its death. It is also toxic to mite ova, though its exact mechanism of action is unknown. In vitro, benzyl benzoate has been found to kill the Sarcoptes mite within 5 minutes.
Pharmacokinetics
- Absorption
- No data are available on percutaneous absorption of benzyl benzoate. Some older studies have suggested some percutaneous absorption, however the amount was not quantified.
- Distribution
- Metabolism
- Rapidly hydrolyzed to benzoic acid and benzyl alcohol, which is further oxidized to benzoic acid. The benzoic acid is conjugated with glycine to form hippuric acid.
- Elimination
Toxicity
Oral, rabbit: LD50 = 1680 mg/kg; Skin, rabbit: LD50 = 4000 mg/kg. Symptoms of overdose include blister formation, crusting, itching, oozing, reddening, or scaling of skin; difficulty in urinating (dribbling); jerking movements; sudden loss of consciousness.
Active Ingredient/Synonyms
Acarobenzyl | Benylate | Benzevan | Benzoate de benzyle | Benzoesäurebenzylester | Benzoic acid phenylmethylester | Benzoic acid, benzyl ester | Benzoic acid, phenylmethyl ester | Benzyl benzoat | Benzylis benzoas | Phenylmethyl benzoate | Benzyl Benzoate |
Source of information: Drugbank (External Link). Last updated on: 3rd July 18. *Trade Name used in the content below may not be the same as the HSA-registered product.