X

BENZYL BENZOATE APPLICATION BP 25% W/V

Product Information

Registration Status: Active

SIN06735P

BENZYL BENZOATE APPLICATION BP 25% W/V is approved to be sold in Singapore with effective from 1991-12-13. It is marketed by ICM PHARMA PTE LTD, with the registration number of SIN06735P.

This product contains Benzyl Benzoate 25% w/v in the form of EMULSION. It is approved for TOPICAL use.

This product is manufactured by ICM PHARMA PTE LTD in SINGAPORE.

It is an Over-the-counter Medicine that can be freely obtained from any retailer

Product Reference
Loading...


Description

Benzyl benzoate is one of the older preparations used to treat scabies. Scabies is a skin infection caused by the mite sarcoptes scabiei. It is characterised by severe itching (particularly at night), red spots, and may lead to a secondary infection. Benzyl benzoate is lethal to this mite and so is useful in the treatment of scabies. It is also used to treat lice infestation of the head and body. Benzyl benzoate is not the treatment of choice for scabies due to its irritant properties.

Indication

Used to kill lice and the mites responsible for the skin condition scabies.

Mechanism of Action

Benzyl benzoate exerts toxic effects on the nervous system of the parasite, resulting in its death. It is also toxic to mite ova, though its exact mechanism of action is unknown. In vitro, benzyl benzoate has been found to kill the Sarcoptes mite within 5 minutes.

Pharmacokinetics

Absorption
No data are available on percutaneous absorption of benzyl benzoate. Some older studies have suggested some percutaneous absorption, however the amount was not quantified.
Distribution
Metabolism
Rapidly hydrolyzed to benzoic acid and benzyl alcohol, which is further oxidized to benzoic acid. The benzoic acid is conjugated with glycine to form hippuric acid.
Elimination

Toxicity

Oral, rabbit: LD50 = 1680 mg/kg; Skin, rabbit: LD50 = 4000 mg/kg. Symptoms of overdose include blister formation, crusting, itching, oozing, reddening, or scaling of skin; difficulty in urinating (dribbling); jerking movements; sudden loss of consciousness.

Active Ingredient/Synonyms

Acarobenzyl | Benylate | Benzevan | Benzoate de benzyle | Benzoesäurebenzylester | Benzoic acid phenylmethylester | Benzoic acid, benzyl ester | Benzoic acid, phenylmethyl ester | Benzyl benzoat | Benzylis benzoas | Phenylmethyl benzoate | Benzyl Benzoate |


Source of information: Drugbank (External Link). Last updated on: 3rd July 18. *Trade Name used in the content below may not be the same as the HSA-registered product.

References

  1. Health Science Authority of Singapore - Reclassified POM
  2. Drugbank

Pharmfair.com uses cookies to improve your browsing experience. We'll assume you're ok with this, but you can opt-out if you wish. Peace!