Product Information

Registration Status: Active

CANESPRO ONCE DAILY CREAM 1% is approved to be sold in Singapore with effective from 2018-02-01. It is marketed by BAYER (SOUTH EAST ASIA) PTE LTD, with the registration number of SIN15415P.

This product contains Bifonazole 0.01mg/g in the form of CREAM. It is approved for TOPICAL use.

This product is manufactured by GP Grenzach Produktions GmbH in SPAIN, andKern Pharma in GERMANY.

It is an Over-the-counter Medicine that can be freely obtained from any retailer



Bifonazole is an azole antifungal drug.


Used for the treatment of various topical fungal infections, including athlete's foot (tinea pedis).

Mechanism of Action

Bifonazole works by inhibiting the production of a substance called ergosterol, which is an essential component of fungal cell membranes.It acts to destabilize the fungal cyctochrome p450 51 enzyme (also known as Lanosterol 14-alpha demethylase). This is vital in the cell membrance structure of the fungus. Its inhibition leads to cell lysis. The disruption in production of ergosterol disrupts the cell membrane and causes holes to appear. The cell membranes of fungi are vital for their survival. They keep unwanted substances from entering the cells and stop the contents of the cells from leaking out. As bifonazole causes holes to appear in the cell membranes, essential constituents of the fungal cells can leak out. This kills the fungi.


Very low absorption following topical administration (0.6% of an applied dose). In cases of skin lesions absorption is increased (2.5%).

Active Ingredient/Synonyms

(+-)-1-(p,alpha-Diphenylbenzyl)imidazole | (+-)1-([1,1'-Biphenyl]-4-ylphenylmethyl)-1H-imidazole | 1-((4-Biphenylyl)phenylmethyl)-1H-imidazole | 1-(alpha-(4-Biphenylyl)benzyl)imidazole | 1-(p,alpha-Diphenylbenzyl)imidazole | Bay h 4502 | Bifonazol | Bifonazolum | Mycospor | Trifonazole | Bifonazole |

Source of information: Drugbank (External Link). Last updated on: 3rd July 18. *Trade Name used in the content below may not be the same as the HSA-registered product.


  1. Health Science Authority of Singapore - Reclassified POM
  2. Drugbank