Product Information
Registration Status: ActiveSIN07957P
COFEN 100 COUGH MIXTURE 100mg/5ml is approved to be sold in Singapore with effective from 1994-09-12. It is marketed by ICM PHARMA PTE LTD, with the registration number of SIN07957P.
This product contains Guaiphenesin 100mg/5ml in the form of SYRUP. It is approved for ORAL use.
This product is manufactured by ICM PHARMA PTE LTD in SINGAPORE.
It is an Over-the-counter Medicine that can be freely obtained from any retailer
Product Reference
Important Note: For generic product, the SPC/PIL provided may not be brand specific.
{{/items}} {{^items}}Description
An expectorant that also has some muscle relaxing action. It is used in many cough preparations. [PubChem]
Indication
Used to assist the expectoration of phlegm from the airways in acute respiratory tract infections.
Mechanism of Action
Guaifenesin may act as an irritant to gastric vagal receptors, and recruit efferent parasympathetic reflexes that cause glandular exocytosis of a less viscous mucus mixture. Cough may be provoked. This combination may flush tenacious, congealed mucopurulent material from obstructed small airways and lead to a temporary improvement in dyspnea or the work of breathing.
Pharmacokinetics
- Absorption
- Rapidly absorbed from the GI tract
- Distribution
- Metabolism
- Rapidly hydrolyzed (60% within seven hours) and then excreted in the urine, with beta-(2-methoxyphenoxy)-lactic acid as its major urinary metabolite.
- Elimination
Toxicity
LD50 1510 mg/kg (rat, oral)
Active Ingredient/Synonyms
Glyceryl guaiacolate | guaiphenesin | Hustosil | Guaifenesin |
Source of information: Drugbank (External Link). Last updated on: 3rd July 18. *Trade Name used in the content below may not be the same as the HSA-registered product.