Product InformationRegistration Status: Active
DEHYDRATED ALCOHOL INJECTION BP is approved to be sold in Singapore with effective from 1991-11-06. It is marketed by PHEBRA (SE ASIA) PTE LTD, with the registration number of SIN06239P.
This product contains Ethanol 100% in the form of INJECTION. It is approved for INTRAVENOUS use.
This product is manufactured by Hospira Australia Pty Ltd in AUSTRALIA.
It is an Over-the-counter Medicine that can be freely obtained from any retailer
A clear, colorless liquid rapidly absorbed from the gastrointestinal tract and distributed throughout the body. It has bactericidal activity and is used often as a topical disinfectant. It is widely used as a solvent and preservative in pharmaceutical preparations as well as serving as the primary ingredient in alcoholic beverages.
For therapeutic neurolysis of nerves or ganglia for the relief of intractable chronic pain in such conditions as inoperable cancer and trigeminal neuralgia (tic douloureux), in patients for whom neurosurgical procedures are contraindicated.
Mechanism of Action
Ethanol affects the brain’s neurons in several ways. It alters their membranes as well as their ion channels, enzymes, and receptors. Alcohol also binds directly to the receptors for acetylcholine, serotonin, GABA, and the NMDA receptors for glutamate. The sedative effects of ethanol are mediated through binding to GABA receptors and glycine receptors (alpha 1 and alpha 2 subunits). It also inhibits NMDA receptor functioning. In its role as an anti-infective, ethanol acts as an osmolyte or dehydrating agent that disrupts the osmotic balance across cell membranes.
- Rapidly absorbed.
- Hepatic. Metabolized by cytochrome P450 enzyme CYP2E1.
Oral, rat LD50: 5628 mg/kg. Symptoms and effects of overdose include nausea, vomiting, CNS depression, acute respiratory failure or death and with chronic use, severe health problems, such as liver and brain damage.
1-Hydroxyethane | Alcohol | Alcohol (ethyl) | Alcohol anhydrous | Alcohol denatured | Alcohol etílico | Alcohol, denatured | Alcool éthylique | Alkohol | Äthanol | Äthylalkohol | Dehydrated ethanol | etanol | éthanol | Ethyl Alcohol | Grain alcohol | Hydroxyethane | Methylcarbinol | Spiritus vini | Ethanol |
Source of information: Drugbank (External Link). Last updated on: 3rd July 18. *Trade Name used in the content below may not be the same as the HSA-registered product.