Product InformationRegistration Status: Active
DUPHALAC SYRUP is approved to be sold in Singapore with effective from 1989-05-18. It is marketed by ABBOTT LABORATORIES (SINGAPORE ) PTE LTD, with the registration number of SIN02818P.
This product contains Lactulose 67g/100ml in the form of SYRUP. It is approved for ORAL use.
This product is manufactured by ABBOTT BIOLOGICALS B V in NETHERLANDS.
It is an Over-the-counter Medicine that can be freely obtained from any retailer
A synthetic disaccharide used in the treatment of constipation and hepatic encephalopathy. It has also been used in the diagnosis of gastrointestinal disorders. (From Martindale, The Extra Pharmacopoeia, 30th ed, p887)
For the treatment of constipation and hepatic encephalopathy.
Mechanism of Action
Lactulose is a synthetic sugar used in the treatment of constipation and liver disease. It consists of the monosaccharides fructose and galactose. In the colon, lactulose is broken down primarily to lactic acid, and also to small amounts of formic and acetic acids, by the action of via evolved-beta galactosidase from colonic bacteria, which results in an increase in osmotic pressure and slight acidification of the colonic contents. This in turn causes an increase in stool water content and softens the stool. In treating heptic diseases (hepatic encephalopathy) it is thought that lactulose draws out ammonia from the body in the same way that it draws out water into the colon.
- Poorly absorbed from the gastrointestinal tract as no human enzyme that is capable of hydrolysis of this disaccharide is present in human gastrointestinal tissue.
- Lactulose is completely metabolized in the colon by enteric bacteria, and no lactulose is excreted in the feces.
LD50=18.2 g/kg (oral, rat). Side effects include diarrhea and resultant dehydration.
4-O-beta-D-Galactopyranosyl-D-fructofuranose | 4-O-beta-D-Galactopyranosyl-D-fructose | Lactulosa | Lactulose | Lactulosum | Lactulose |
Source of information: Drugbank (External Link). Last updated on: 3rd July 18. *Trade Name used in the content below may not be the same as the HSA-registered product.