Product Information
Registration Status: ActiveSIN03440P
INON GRANULES is approved to be sold in Singapore with effective from 1989-08-06. It is marketed by SATO PHARMACEUTICAL (SINGAPORE) PTE LTD, with the registration number of SIN03440P.
This product contains Aluminium Hydroxide 525mg/1.8g,Magnesium Carbonate 350mg/1.8g, and Sodium Bicarbonate 525mg/1.8 g in the form of GRANULE. It is approved for ORAL use.
This product is manufactured by SATO PHARMACEUTICAL CO LTD in JAPAN.
It is an Over-the-counter Medicine that can be freely obtained from any retailer
Product Reference
Important Note: For generic product, the SPC/PIL provided may not be brand specific.
{{/items}} {{^items}}Description
Aluminum hydroxide is an inorganic salt used as an antacid. It is a basic compound that acts by neutralizing hydrochloric acid in gastric secretions. Subsequent increases in pH may inhibit the action of pepsin. An increase in bicarbonate ions and prostaglandins may also confer cytoprotective effects.
Indication
For relief of heartburn and acid indigestion.
Mechanism of Action
Aluminum hydroxide is a basic inorganic salt that acts by neutralizing hydrochloric acid in gastric secretions. Aluminum hydroxide is slowly solubilized in the stomach and reacts with hydrochloric acid to form aluminum chloride and water. It also inhibits the action of pepsin by increasing the pH and via adsorption. Cytoprotective effects may occur through increases in bicarbonate ion (HCO3-) and prostaglandins.
Pharmacokinetics
- Absorption
- Approximately 17-30% of the aluminum chloride formed is absorbed.
- Distribution
- Metabolism
- Not metabolized.
- Elimination
Active Ingredient/Synonyms
Aluminium hydroxide | Aluminium hydroxide gel, dried | Aluminium hydroxide, dried | Aluminum hydroxide gel, dried | Aluminum hydroxide, dried | Dried aluminium hydroxide | Dried aluminum hydroxide gel | Aluminum hydroxide |
Source of information: Drugbank (External Link). Last updated on: 3rd July 18. *Trade Name used in the content below may not be the same as the HSA-registered product.
Description
Magnesium carbonate, also known as magnesite, is a common over the counter remedy for heartburn and upset stomach caused by overproduction of acid in the stomach [FDA Label].
Indication
Used as an over the counter antacid [L593].
Mechanism of Action
Magnesium carbonate reacts with hydrochloric acid in the stomach to form carbon dioxide and magnesium chloride thus neutralizing excess acid in the stomach [L593].
Pharmacokinetics
- Absorption
- About 40-60% of magnesium is absorbed following oral administration [L593]. Percent absorption decreases as dose increases.
- Distribution
- Vd for magnesium is 0.2-0.4L/kg [L593]. About 50% distributes to bone.
- Metabolism
- Magnesium does not appear to be metabolized in any way [L593].
- Elimination
Clearance
Maximum magnesium clearance is directly proportional to creatinine clearance [L593].
Toxicity
During overdose, magnesium impairs neuromuscular transmission resulting in weakness and hypoflexia [L593].
Active Ingredient/Synonyms
Magnesium carbonate | Magnesium carbonate |
Source of information: Drugbank (External Link). Last updated on: 3rd July 18. *Trade Name used in the content below may not be the same as the HSA-registered product.
Description
Sodium bicarbonate is a white, crystalline powder that is commonly used as a pH buffering agent, an electrolyte replenisher, systemic alkalizer and in topical cleansing solutions.
Indication
Sodium bicarbonate is used for the treatment of metabolic acidosis which may occur in severe renal disease, uncontrolled diabetes, circulatory insufficiency due to shock or severe dehydration, extracorporeal circulation of blood, cardiac arrest and severe primary lactic acidosis. Also is indicated in severe diarrhea which is often accompanied by a significant loss of bicarbonate. Further indicated in the treatment of certain drug intoxications, including barbiturates (where dissociation of the barbiturateprotein complex is desired), in poisoning by salicylates or methyl alcohol and in hemolytic reactions requiring alkalinization of the urine to diminish nephrotoxicity of blood pigments.
Mechanism of Action
Sodium bicarbonate is a systemic alkalizer, which increases plasma bicarbonate, buffers excess hydrogen ion concentration, and raises blood pH, thereby reversing the clinical manifestations of acidosis. It is also a urinary alkalizer, increasing the excretion of free bicarbonate ions in the urine, thus effectively raising the urinary pH. By maintaining an alkaline urine, the actual dissolution of uric acid stones may be accomplished. Sodium bicarbonate acts as an antacid and reacts chemically to neutralize or buffer existing quantities of stomach acid but has no direct effect on its output. This action results in increased pH value of stomach contents, thus providing relief of hyperacidity symptoms. [PharmGKB]
Active Ingredient/Synonyms
Baking soda | Bicarbonate of soda | Carbonic acid monosodium salt | e 500 | e-500 | e500 | NaHCO3 | Natriumhydrogenkarbonat | Sodium acid carbonate | Sodium bicarbonate | Sodium hydrogen carbonate | Sodium hydrogencarbonate | Sodium bicarbonate |
Source of information: Drugbank (External Link). Last updated on: 3rd July 18. *Trade Name used in the content below may not be the same as the HSA-registered product.