Product Information
Registration Status: ActiveKAOLIN & PECTIN MIXTURE is approved to be sold in Singapore with effective from 1991-05-23. It is marketed by DRUG HOUSES OF AUSTRALIA PTE LTD, with the registration number of SIN06268P.
This product contains Kaolin Light 1g/5ml, and Pectin 50mg/5ml in the form of SUSPENSION. It is approved for ORAL use.
This product is manufactured by PT. ACTAVIS INDONESIA in INDONESIA REP OF.
It is an Over-the-counter Medicine that can be freely obtained from any retailer
Source of information: Drugbank (External Link). Last updated on: 3rd July 18. *Trade Name used in the content below may not be the same as the HSA-registered product.
Description
Pectin is a heteropolysaccharide commercially derived from the cell wall of higher plants.[A32327] It is composed of partially methylated polygalacturonic acid units linked in the positions 1-4.[L1961] The carboxylic group of the constituents of pectin can exist in the form of esters, free acids, ammonium, potassium or sodium salts or as acid amides. Under the FDA regulation, pectin qualifies as a GRAS (generally recognized as safe) food substance. This status allows pectin to be used with no limitations.[L1960]
Indication
Pectin is used in food as a gelling agent and stabilizer. As a medical drug, it has obtained a great interest in its potential use as a source of dietary fiber, lipid, cholesterol, serum glucose and insulin level lowering effect, gastric emptying delay.[A32327] Some recent studies have researched the possibility of using pectin for the formation of nanoparticles as a delivery vehicle of drugs.[A32331]
Mechanism of Action
Pectin is an adsorbent that binds to bacteria, toxins and other irritants in the intestinal mucosa. Pectin is able to decrease the pH in the intestinal lumen and provides a soothing effect on the irritated mucosa.[T150]
Pharmacokinetics
- Absorption
- Pectin is not absorbed and it is not distributed in the body.[T150]
- Distribution
- Pharmacokinetic studies have not been performed as pectin is not absorbed.
- Metabolism
- Pectin is depolymerized and de-esterified to a very small extent. It passes to the small intestine as a macromolecule and the majority of the pectin is eliminated unchanged.[L1962]
- Elimination
Clearance
Pharmacokinetic studies have not been performed as pectin is not absorbed.
Toxicity
Pectin is a substance determined to be safe.
Active Ingredient/Synonyms
Pectin | Pectin |
Source of information: Drugbank (External Link). Last updated on: 3rd July 18. *Trade Name used in the content below may not be the same as the HSA-registered product.