Product Information
Registration Status: ActiveKONAKION MM INJECTION 10mg/ML is approved to be sold in Singapore with effective from 1996-01-27. It is marketed by ROCHE SINGAPORE PTE LTD, with the registration number of SIN08533P.
This product contains Phytomenadione 10mg/ml in the form of INJECTION. It is approved for INTRAVENOUS use.
This product is manufactured by CENEXI SAS in SWITZERLAND, andF HOFFMANN-LA ROCHE & CO LTD in FRANCE.
It is an Over-the-counter Medicine that can be freely obtained from any retailer
Description
Phylloquinone is often called vitamin K1. It is a fat-soluble vitamin that is stable to air and moisture but decomposes in sunlight. It is found naturally in a wide variety of green plants. Phylloquinone is also an antidote for coumatetralyl. Vitamin K is needed for the posttranslational modification of certain proteins, mostly required for blood coagulation.
Indication
For the treatment of haemorrhagic conditions in infants, antidote for coumarin anticoagulants in hypoprothrombinaemia.
Mechanism of Action
Vitamin K is an essential cofactor for the gamma-carboxylase enzymes which catalyze the posttranslational gamma-carboxylation of glutamic acid residues in inactive hepatic precursors of coagulation factors II (prothrombin), VII, IX and X. Gamma-carboxylation converts these inactive precursors into active coagulation factors which are secreted by hepatocytes into the blood. Supplementing with Phylloquinone results in a relief of vitamin K deficiency symptoms which include easy bruisability, epistaxis, gastrointestinal bleeding, menorrhagia and hematuria.
Pharmacokinetics
- Absorption
- Oral phylloquinone is adequately absorbed from the gastrointestinal tract only if bile salts are present. After absorption, phylloquinone is initially concentrated in the liver, but the concentration declines rapidly. Very little vitamin K accumulates in tissues.
- Distribution
- Metabolism
- Elimination
Toxicity
The intravenous LD50 of phylloquinone in the mouse is 41.5 and 52 mL/kg for the 0.2% and 1% concentrations, respectively.
Active Ingredient/Synonyms
2-Methyl-3-(3,7,11,15-tetramethyl-2-hexadecenyl)-1,4-naphthalenedione | 2-Methyl-3-[(2e)-3,7,11,15-tetramethyl-2-hexadecenyl]naphthoquinone | 2-Methyl-3-phytyl-1,4-naphthochinon | 2-Methyl-3-phytyl-1,4-naphthoquinone | 3-Phytylmenadione | alpha-Phylloquinone | Fitomenadiona | Phyllochinon | Phyllochinonum | Phylloquinone | Phythyl-menadion | Phytomenadione | Phytomenadionum | Phytonadionum | Phytylmenadione | trans-Phylloquinone | Vitamin k | Vitamin K1 | α-phylloquinone | Phylloquinone |
Source of information: Drugbank (External Link). Last updated on: 3rd July 18. *Trade Name used in the content below may not be the same as the HSA-registered product.