Product Information
Registration Status: ActiveMAGTASIL ANTACID MIXTURE is approved to be sold in Singapore with effective from 1996-03-07. It is marketed by ICM PHARMA PTE LTD, with the registration number of SIN08786P.
This product contains Magnesium Carbonatet 5% w/v,Magnesium Trisilicate 5% w/v, and Sodium Bicarbonate 5% w/v in the form of SUSPENSION. It is approved for ORAL use.
This product is manufactured by ICM PHARMA PTE LTD in SINGAPORE.
It is an Over-the-counter Medicine that can be freely obtained from any retailer
Source of information: Drugbank (External Link). Last updated on: 3rd July 18. *Trade Name used in the content below may not be the same as the HSA-registered product.
Description
Magnesium trisilicate is an inorganic compound that is used as an antacid in the treatment of peptic ulcers.
Indication
For the treatment of peptic ulcers. Relieving indigestion and heartburn.
Mechanism of Action
The gelatinous silicon dioxide, formed by the reaction of magnesium trisilicate with gastric contents is said to protect ulcerated mucosal surfaces and favor healing.
Pharmacokinetics
- Absorption
- The hydrated silicon dioxide formed in the stomach and passes into the intestinal track where, silica can be partly absorbed.
- Distribution
- The hydrated silicon dioxide formed in the stomach and passes into the intestinal track.
- Metabolism
- Elimination
Clearance
Maximum magnesium clearance is directly proportional to creatinine clearance.
Toxicity
Adequate doses of magnesium trisilicate may cause diarrhea due to the action of soluble magnesium salts in the enteric tract. Approx 5% of the magnesium is absorbed.
Active Ingredient/Synonyms
Magnesium Trisilicate | Magnesium Trisilicate |
Source of information: Drugbank (External Link). Last updated on: 3rd July 18. *Trade Name used in the content below may not be the same as the HSA-registered product.
Description
Sodium bicarbonate is a white, crystalline powder that is commonly used as a pH buffering agent, an electrolyte replenisher, systemic alkalizer and in topical cleansing solutions.
Indication
Sodium bicarbonate is used for the treatment of metabolic acidosis which may occur in severe renal disease, uncontrolled diabetes, circulatory insufficiency due to shock or severe dehydration, extracorporeal circulation of blood, cardiac arrest and severe primary lactic acidosis. Also is indicated in severe diarrhea which is often accompanied by a significant loss of bicarbonate. Further indicated in the treatment of certain drug intoxications, including barbiturates (where dissociation of the barbiturateprotein complex is desired), in poisoning by salicylates or methyl alcohol and in hemolytic reactions requiring alkalinization of the urine to diminish nephrotoxicity of blood pigments.
Mechanism of Action
Sodium bicarbonate is a systemic alkalizer, which increases plasma bicarbonate, buffers excess hydrogen ion concentration, and raises blood pH, thereby reversing the clinical manifestations of acidosis. It is also a urinary alkalizer, increasing the excretion of free bicarbonate ions in the urine, thus effectively raising the urinary pH. By maintaining an alkaline urine, the actual dissolution of uric acid stones may be accomplished. Sodium bicarbonate acts as an antacid and reacts chemically to neutralize or buffer existing quantities of stomach acid but has no direct effect on its output. This action results in increased pH value of stomach contents, thus providing relief of hyperacidity symptoms. [PharmGKB]
Active Ingredient/Synonyms
Baking soda | Bicarbonate of soda | Carbonic acid monosodium salt | e 500 | e-500 | e500 | NaHCO3 | Natriumhydrogenkarbonat | Sodium acid carbonate | Sodium bicarbonate | Sodium hydrogen carbonate | Sodium hydrogencarbonate | Sodium bicarbonate |
Source of information: Drugbank (External Link). Last updated on: 3rd July 18. *Trade Name used in the content below may not be the same as the HSA-registered product.