MICONAZOLE CREAM 2% W/W FOR TOPICAL USE

Product Information

Registration Status: Active

SW MICONAZOLE CREAM 2% W/W is approved to be sold in Singapore with effective from 1990-02-21. It is marketed by SUNWARD PHARMACEUTICAL PTE LTD, with the registration number of SIN03904P.

This product contains Miconazole 2% w/w in the form of CREAM. It is approved for TOPICAL use.

This product is manufactured by SUNWARD PHARMACEUTICAL PRIVATE LIMITED in SINGAPORE, andSUNWARD PHARMACEUTICAL SDN BHD in MALAYSIA.

It is an Over-the-counter Medicine that can be freely obtained from any retailer

Description

An imidazole antifungal agent that is used topically and by intravenous infusion. [PubChem]

Indication

For topical application in the treatment of tinea pedis (athlete’s foot), tinea cruris, and tinea corporis caused by Trichophyton rubrum, Trichophyton mentagrophytes, and Epidermophyton floccosum, in the treatment of cutaneous candidiasis (moniliasis), and in the treatment of tinea versicolor.

Mechanism of Action

Miconazole interacts with 14-α demethylase, a cytochrome P-450 enzyme necessary to convert lanosterol to ergosterol. As ergosterol is an essential component of the fungal cell membrane, inhibition of its synthesis results in increased cellular permeability causing leakage of cellular contents. Miconazole may also inhibit endogenous respiration, interact with membrane phospholipids, inhibit the transformation of yeasts to mycelial forms, inhibit purine uptake, and impair triglyceride and/or phospholipid biosynthesis.

Toxicity

Oral, mouse: LD₅₀ = 3800 mg/kg; Oral, rat: LD₅₀ = 3 gm/kg. Ingestion of the amounts of the components contained in a tube of cream are unlikely to produce overdosage and toxic effects.

Active Ingredient/Synonyms

Source of information: Drugbank (External Link). Last updated on: 3^rd July 18. *Trade Name used in the content below may not be the same as the HSA-registered product.