Product Information
Registration Status: ActiveSIN13931P
PANAMAX PATCH 60MG/12G is approved to be sold in Singapore with effective from 2011-03-15. It is marketed by GSK CONSUMER HEALTHCARE SINGAPORE PTE LTD, with the registration number of SIN13931P.
This product contains Diclofenac 60mg/12g in the form of PATCH. It is approved for TOPICAL use.
This product is manufactured by Teh Seng Pharmaceutical Mfg. Co. Ltd. in TAIWAN.
It is an Over-the-counter Medicine that can be freely obtained from any retailer
Product Reference
Important Note: For generic product, the SPC/PIL provided may not be brand specific.
{{/items}} {{^items}}Description
A non-steroidal anti-inflammatory agent (NSAID) with antipyretic and analgesic actions. It is primarily available as the sodium salt. [PubChem]
Indication
For the acute and chronic treatment of signs and symptoms of osteoarthritis and rheumatoid arthritis.
Mechanism of Action
The antiinflammatory effects of diclofenac are believed to be due to inhibition of both leukocyte migration and the enzyme cylooxygenase (COX-1 and COX-2), leading to the peripheral inhibition of prostaglandin synthesis. As prostaglandins sensitize pain receptors, inhibition of their synthesis is responsible for the analgesic effects of diclofenac. Antipyretic effects may be due to action on the hypothalamus, resulting in peripheral dilation, increased cutaneous blood flow, and subsequent heat dissipation.
Pharmacokinetics
- Absorption
- Completely absorbed from the gastrointestinal tract.
- Distribution
- * 1.3 L/kg
- Metabolism
- Hepatic
- Elimination
Clearance
* oral cl=622 mL/min [healthy] * renal cl
Toxicity
Symptoms of overdose include loss of consciousness, increased intracranial pressure, and aspiration pneumonitis. LD50=390mg/kg (orally in mice)
Active Ingredient/Synonyms
[2-(2,6-dichloroanilino)phenyl]acetic acid | 2-((2,6-dichlorophenyl)amino)benzeneacetic acid | Diclofenac Acid | Diclofenaco | Diclofenacum | Diclofenac |
Source of information: Drugbank (External Link). Last updated on: 3rd July 18. *Trade Name used in the content below may not be the same as the HSA-registered product.