Product Information
Registration Status: ActiveRENNIE TABLET is approved to be sold in Singapore with effective from 1996-05-27. It is marketed by BAYER (SOUTH EAST ASIA) PTE LTD, with the registration number of SIN08733P.
This product contains Calcium Carbonate 680mg, and Magnesium Carbonate Heavy 80mg in the form of TABLET. It is approved for ORAL use.
This product is manufactured by Delpharm Gaillard in FRANCE.
It is an Over-the-counter Medicine that can be freely obtained from any retailer
Description
Calcium carbonate is an inorganic salt used as an antacid. It is a basic compound that acts by neutralizing hydrochloric acid in gastric secretions. Subsequent increases in pH may inhibit the action of pepsin. An increase in bicarbonate ions and prostaglandins may also confer cytoprotective effects. Calcium carbonate may also be used as a nutritional supplement or to treat hypocalcemia.
Indication
For relief of heartburn and acid indigestion. May also be used as a nutritional supplement or to treat hypocalcemia.
Mechanism of Action
Calcium carbonate is a basic inorganic salt that acts by neutralizing hydrochloric acid in gastric secretions. It also inhibits the action of pepsin by increasing the pH and via adsorption. Cytoprotective effects may occur through increases in bicarbonate ion (HCO3-) and prostaglandins. Neutralization of hydrochloric acid results in the formation of calcium chloride, carbon dioxide and water. Approximately 90% of calcium chloride is converted to insoluble calcium salts (e.g. calcium carbonate and calcium phosphate).
Pharmacokinetics
- Absorption
- Maximal absorption occurs at doses of 500 mg or less taken with food. Oral bioavailability depends on intestinal pH, the presence of food and dosage.
- Distribution
- Calcium is rapidly distributed taken up by skeletal tissues following absorption and distribution into extracellular fluids. Bone contains 99% of the body's calcium and the remaining 1% is approximately equally distributed between intracellular and extracellular fluids.
- Metabolism
- None.
- Elimination
Active Ingredient/Synonyms
CaCO3 | Calcium carbonate | Calcium carbonate (1:1) | Calciumcarbonat | Carbonate de calcium | Carbonato de calcio | Carbonic acid calcium salt (1:1) | Chalk | E 170 | Kalziumkarbonat | Kohlensaurer kalk | Precipitated calcium carbonate | Calcium Carbonate |
Source of information: Drugbank (External Link). Last updated on: 3rd July 18. *Trade Name used in the content below may not be the same as the HSA-registered product.
Source of information: Drugbank (External Link). Last updated on: 3rd July 18. *Trade Name used in the content below may not be the same as the HSA-registered product.