Product Information
Registration Status: ActiveSIN07304P
SCHOLL ATHLETE'S FOOT SPRAY 1% W/V is approved to be sold in Singapore with effective from 1993-01-13. It is marketed by RECKITT BENCKISER (SINGAPORE) PTE LTD, with the registration number of SIN07304P.
This product contains Tolnaftate 1% w/v in the form of SPRAY. It is approved for TOPICAL use.
This product is manufactured by Colep Laupheim GmbH & Co. KG in GERMANY.
It is an Over-the-counter Medicine that can be freely obtained from any retailer
Product Reference
Important Note: For generic product, the SPC/PIL provided may not be brand specific.
{{/items}} {{^items}}Description
Tolnaftate is a synthetic over-the-counter anti-fungal agent. It may come as a cream, powder, spray, or liquid aerosol, and is used to treat jock itch, athlete's foot and ringworm. It is sold under several brand names, most notably Tinactin and Odor Eaters.
Indication
Tolnaftate topical is used to treat skin infections such as athlete's foot, jock itch, and ringworm infections. Tolnaftate is also used, along with other antifungals, to treat infections of the nails, scalp, palms, and soles of the feet. The powder and powder aerosol may be used to prevent athlete's foot.
Mechanism of Action
Tolnaftate is a topical fungicide. Though its exact mechanism unknown, it is believed to prevent ergosterol biosynthesis by inhibiting squalene epoxidase. It has also been reported to distort the hyphae and to stunt mycelial growth in susceptible organisms.
Toxicity
Oral rat LD50: 891 mg/kg. Inhalation rat LC50: > 900 mg/m3/1hr. Irritation: skin rabbit: 500 mg/24H mild. Eye rabbit: 100 mg severe. Investigated a mutagen and reproductive effector.
Active Ingredient/Synonyms
2-Naphthyl N-methyl-N-(3-tolyl)thionocarbamate | m,N-Dimethylthiocarbanilic acid O-2-naphthyl ester | Methyl (3-methylphenyl)carbamothioic acid O-2-naphthalenyl ester | N-Methyl-N-(3-methylphenyl)-1-(naphthalen-2-yloxy)methanethioamide | O-2-Naphthyl m,N-dimethylthiocarbanilate | Separin | Tolnaftato | Tolnaftatum | Tolnaphthate | Tolnaftate |
Source of information: Drugbank (External Link). Last updated on: 3rd July 18. *Trade Name used in the content below may not be the same as the HSA-registered product.