Product Information
Registration Status: ActiveSICCAFLUID EYE GEL 0.25% is approved to be sold in Singapore with effective from 2005-10-03. It is marketed by DCH AURIGA SINGAPORE, with the registration number of SIN13063P.
This product contains Carbomer 0.25 G in the form of GEL. It is approved for OPHTHALMIC use.
This product is manufactured by URSAPHARM ARZNEIMITTEL GMBH & CO KG in GERMANY.
It is an Over-the-counter Medicine that can be freely obtained from any retailer
Description
Carbopol 974P is a highly carboxylated polymer composed of lightly cross-linked polyacrylic acid with a broad-spectrum mechanism based on acidification of pathogens. It was under development by ReProtect LLC. It is a gel that may help both block the spread of sexually transmitted diseases and reduce unwanted pregnancies. The compound, known as BufferGel, was in advanced clinical trials for its ability to prevent pregnancy, but was discontinued.
Indication
Investigated for use/treatment in contraception and HIV prevention.
Mechanism of Action
BufferGel is a microbicidal spermicide that provides sufficient buffering activity to maintain the mild, protective acidity of the vagina in the presence of semen. Sperm are acid-sensitive, so to assure fertility, semen provides a powerful alkalinizing action that abolishes the protective acidity of the vagina for several hours after intercourse. This alkalinizing action of semen also enables acid-sensitive sexually transmitted diseases (STD) pathogens to transmit infection. By blocking this action of semen, BufferGel prevents unwanted pregnancy, and shows promise for prevention of STDs, including HIV/AIDS.
Active Ingredient/Synonyms
BufferGel | Carbomer 974 (P) | Carbomer 974P | carbomer homopolymer type b | Carbomer homopolymer type B (allyl pentaerythritol crosslinked) | Carbomer-974P | Carbopol polymer | Carbopol 974P |
Source of information: Drugbank (External Link). Last updated on: 3rd July 18. *Trade Name used in the content below may not be the same as the HSA-registered product.