Product Information
Registration Status: ActiveSOLVEASY TINEA CREAM 1% w/w is approved to be sold in Singapore with effective from 2017-07-07. It is marketed by EGO PHARMACEUTICALS (SINGAPORE) PTE LTD, with the registration number of SIN15296P.
This product contains Terbinafine 1% w/w in the form of CREAM. It is approved for TOPICAL use.
This product is manufactured by Ego Pharmaceuticals Pty Ltd in AUSTRALIA.
It is an Over-the-counter Medicine that can be freely obtained from any retailer
Description
Terbinafine hydrochloride (Lamisil) is a synthetic allylamine antifungal. It is highly lipophilic in nature and tends to accumulate in skin, nails, and fatty tissues. Like other allylamines, terbinafine inhibits ergosterol synthesis by inhibiting the fungal squalene monooxygenase (squalene 2,3-epoxidase), an enzyme that is part of the fungal cell wall synthesis pathway.
Indication
For the treatment of dermatophyte infections of the toenail or fingernail caused by susceptible fungi. Also for the treatment of tinea capitis (scalp ringworm) and tinea corporis (body ringworm) or tinea cruris (jock itch).
Mechanism of Action
Terbinafine is hypothesized to act by inhibiting squalene monooxygenase, thus blocking the biosynthesis of ergosterol, an essential component of fungal cell membranes. This inhibition also results in an accumulation of squalene, which is a substrate catalyzed to 2,3-oxydo squalene by squalene monooxygenase. The resultant high concentration of squalene and decreased amount of ergosterol are both thought to contribute to terbinafine's antifungal activity.
Pharmacokinetics
- Absorption
- Readily absorbed from gastrointestinal tract.
- Distribution
- Metabolism
- Hepatic
- Elimination
Active Ingredient/Synonyms
(e)-N-(6,6-Dimethyl-2-hepten-4-ynyl)-N-methyl-1-naphthalene methanamine | (e)-N-(6,6-Dimethyl-2-hepten-4-ynyl)-N-methyl-1-naphthalenemethylamine | Terbinafina | Terbinafinum | Terbinafine |
Source of information: Drugbank (External Link). Last updated on: 3rd July 18. *Trade Name used in the content below may not be the same as the HSA-registered product.