Product Information
Registration Status: ActiveTROPEX EAR DROPS 5% W/V is approved to be sold in Singapore with effective from 1990-06-26. It is marketed by DCH AURIGA SINGAPORE, with the registration number of SIN04739P.
This product contains Phenazone 5% w/v in the form of SOLUTION. It is approved for AURICULAR (OTIC) use.
This product is manufactured by ROWA PHARMACEUTICALS LTD in IRELAND.
It is an Over-the-counter Medicine that can be freely obtained from any retailer
Description
An analgesic and antipyretic that has been given by mouth and as ear drops. Antipyrine is often used in testing the effects of other drugs or diseases on drug-metabolizing enzymes in the liver. (From Martindale, The Extra Pharmacopoeia, 30th ed, p29)
Indication
Antipyrine is an analgesic often used to test effects of other drugs on liver enzymes..
Mechanism of Action
Antipyrine is thought to act primarily in the CNS, increasing the pain threshold by inhibiting both isoforms of cyclooxygenase, COX-1, COX-2, and COX-3 enzymes involved in prostaglandin (PG) synthesis.
Active Ingredient/Synonyms
1,2-Dihydro-1,5-dimethyl-2-phenyl-3H-pyrazol-3-one | 2,3-Dimethyl-1-phenyl-5-pyrazolone | Analgesine | Antipyrine | Fenazon | Fenazona | Phenazon | Phenazone | Antipyrine |
Source of information: Drugbank (External Link). Last updated on: 3rd July 18. *Trade Name used in the content below may not be the same as the HSA-registered product.