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ADEZIO ORAL SOLUTION 1mg/ML

Product Information

Registration Status: Active

SIN12518P

ADEZIO ORAL SOLUTION 1mg/ML is approved to be sold in Singapore with effective from 2004-02-20. It is marketed by APEX PHARMA MARKETING PTE LTD, with the registration number of SIN12518P.

This product contains Cetirizine 1mg/ml in the form of SOLUTION. It is approved for ORAL use.

This product is manufactured by XEPA-SOUL PATTINSON (MALAYSIA) SDN BHD in MALAYSIA.

It is a Pharmacy Only Medicine that can be obtained from a pharmacist at a retail pharmacy.

Product Reference
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Description

A potent second-generation histamine H1 antagonist that is effective in the treatment of allergic rhinitis, chronic urticaria, and pollen-induced asthma. Unlike many traditional antihistamines, it does not cause drowsiness or anticholinergic side effects. [PubChem]

Indication

For the relief of symptoms associated with seasonal allergic rhinitis, perennial allergic rhinitis and the treatment of the uncomplicated skin manifestations of chronic idiopathic urticaria

Mechanism of Action

Cetirizine competes with histamine for binding at H1-receptor sites on the effector cell surface, resulting in suppression of histaminic edema, flare, and pruritus. The low incidence of sedation can be attributed to reduced penetration of cetirizine into the CNS as a result of the less lipophilic carboxyl group on the ethylamine side chain.

Pharmacokinetics

Absorption
mean peak plasma concentration (Cmax) of 114 ng/mL at a time (Tmax) of 2.2 hours postdose was observed for cetirizine
Distribution
Metabolism
Elimination

Clearance

* 53 mL/min [healthy]

Toxicity

Somnolence (sleepiness or unusual drowsiness), restlessness, irritability

Active Ingredient/Synonyms

Cetirizin | Cetirizina | Cetirizinum | Cetirizine |


Source of information: Drugbank (External Link). Last updated on: 3rd July 18. *Trade Name used in the content below may not be the same as the HSA-registered product.

References

  1. Health Science Authority of Singapore - Reclassified POM
  2. Drugbank

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