Product Information

Registration Status: Active

ALCAINE STERILE OPHTHALMIC SOLUTION 0.5% is approved to be sold in Singapore with effective from 1990-06-13. It is marketed by ALCON PTE LTD, with the registration number of SIN04718P.

This product contains Proparacaine 0.50% in the form of SOLUTION. It is approved for OPHTHALMIC use.

This product is manufactured by ALCON-COUVREUR NV in BELGIUM.

It is a Pharmacy Only Medicine that can be obtained from a pharmacist at a retail pharmacy.



Proparacaine is a topical anesthetic drug of the amino ester group. It is available as its hydrochloride salt in ophthalmic solutions at a concentration of 0.5%.


Used as a local (ophthalmic) anesthetic.

Mechanism of Action

The exact mechanism whereby proparacaine and other local anesthetics influence the permeability of the cell membrane is unknown; however, several studies indicate that local anesthetics may limit sodium ion permeability through the lipid layer of the nerve cell membrane. Proparacaine may alter epithelial sodium channels through interaction with channel protein residues. This limitation prevents the fundamental change necessary for the generation of the action potential.

Active Ingredient/Synonyms

Proximetacaina | Proxymetacaine | Proxymetacainum | Proparacaine |

Source of information: Drugbank (External Link). Last updated on: 3rd July 18. *Trade Name used in the content below may not be the same as the HSA-registered product.


  1. Health Science Authority of Singapore - Reclassified POM
  2. Drugbank