Product Information
Registration Status: ActiveALINAMIN-F ODORLESS TABLET is approved to be sold in Singapore with effective from 1991-06-21. It is marketed by LUEN WAH MEDICAL COMPANY (SINGAPORE) PTE LTD, with the registration number of SIN06298P.
This product contains Fursultiamine 50mg, and Riboflavin 5mg in the form of TABLET, SUGAR-COATED. It is approved for ORAL use.
This product is manufactured by INTERTHAI PHARMACEUTICAL MANUFACTURING LTD in THAILAND.
It is a Pharmacy Only Medicine that can be obtained from a pharmacist at a retail pharmacy.
Description
Compound used for therapy of thiamine deficiency. It has also been suggested for several non-deficiency disorders but has not yet proven useful. Fursultiamine is a vitamin B1 derivative.
Active Ingredient/Synonyms
Fursultiamine | Fursultiamine |
Source of information: Drugbank (External Link). Last updated on: 3rd July 18. *Trade Name used in the content below may not be the same as the HSA-registered product.
Description
Nutritional factor found in milk, eggs, malted barley, liver, kidney, heart, and leafy vegetables. The richest natural source is yeast. It occurs in the free form only in the retina of the eye, in whey, and in urine; its principal forms in tissues and cells are as flavin mononucleotide and flavin-adenine dinucleotide.
Indication
For the treatment of ariboflavinosis (vitamin B2 deficiency).
Mechanism of Action
Binds to riboflavin hydrogenase, riboflavin kinase, and riboflavin synthase. Riboflavin is the precursor of flavin mononucleotide (FMN, riboflavin monophosphate) and flavin adenine dinucleotide (FAD). The antioxidant activity of riboflavin is principally derived from its role as a precursor of FAD and the role of this cofactor in the production of the antioxidant reduced glutathione. Reduced glutathione is the cofactor of the selenium-containing glutathione peroxidases among other things. The glutathione peroxidases are major antioxidant enzymes. Reduced glutathione is generated by the FAD-containing enzyme glutathione reductase.
Pharmacokinetics
- Absorption
- Vitamin B2 is readily absorbed from the upper gastrointestinal tract.
- Distribution
- Metabolism
- Hepatic.
- Elimination
Active Ingredient/Synonyms
1-Deoxy-1-(7,8-dimethyl-2,4-dioxo-3,4-dihydrobenzo[g]pteridin-10(2H)-yl)pentitol | 6,7-Dimethyl-9-D-ribitylisoalloxazine | 7,8-Dimethyl-10-(D-ribo-2,3,4,5-tetrahydroxypentyl)isoalloxazine | 7,8-Dimethyl-10-ribitylisoalloxazine | Lactoflavin | Lactoflavine | Riboflavina | Riboflavine | Riboflavinum | Vitamin B2 | Vitamin Bi | Vitamin G | Riboflavin |
Source of information: Drugbank (External Link). Last updated on: 3rd July 18. *Trade Name used in the content below may not be the same as the HSA-registered product.