Product Information
Registration Status: ActiveSIN02589P
AMYL NITRITE INHALANT USP 0.3ml/AMPOULE is approved to be sold in Singapore with effective from 1989-04-22. It is marketed by MEDSUPPLY INTERNATIONAL (NUTRACARE PHARMA PTE LTD), with the registration number of SIN02589P.
This product contains Amyl Nitrite 0.3ml/ampoule in the form of SOLUTION. It is approved for RESPIRATORY (INHALATION) use.
This product is manufactured by JAMES ALEXANDER CORPN in UNITED STATES.
It is a Pharmacy Only Medicine that can be obtained from a pharmacist at a retail pharmacy.
Product Reference
Important Note: For generic product, the SPC/PIL provided may not be brand specific.
{{/items}} {{^items}}Description
Amyl Nitrite is an antihypertensive medicine. Amyl nitrite is employed medically to treat heart diseases such as angina and to treat cyanide poisoning. Like other alkyl nitrites, amyl nitrite is bioactive in mammals, being a vasodilator which is the basis of its use as a prescription medicine. As an inhalant, it also has psychoactive effect which has led to illegal drug use.
Indication
For the rapid relief of angina pectoris.
Mechanism of Action
Amyl nitrite's antianginal action is thought to be the result of a reduction in systemic and pulmonary arterial pressure (afterload) and decreased cardiac output because of peripheral vasodilation, rather than coronary artery dilation. Amyl nitrite is a source of nitric acid, which accounts for the mechanism described above. As an antidote (to cyanide poisoning), amyl nitrite promotes formation of methemoglobin, which combines with cyanide to form nontoxic cyanmethemoglobin.
Pharmacokinetics
- Absorption
- Amyl nitrite vapors are absorbed rapidly through the pulmonary alveoli, manifesting therapeutic effects within one minute after inhalation.
- Distribution
- Metabolism
- Hepatic. The drug is metabolized rapidly, probably by hydrolytic denitration; approximately one-third of the inhaled amyl nitrite is excreted in the urine.
- Elimination
Toxicity
Overdose symptoms include nausea, emesis (vomiting), hypotension, hypoventilation, dyspnea (shortness of breath), and syncope (fainting)
Active Ingredient/Synonyms
1-nitropentane | n-Amyl nitrite | n-pentyl nitrite | Nitramyl | pentyl nitrite | Amyl Nitrite |
Source of information: Drugbank (External Link). Last updated on: 3rd July 18. *Trade Name used in the content below may not be the same as the HSA-registered product.