Product Information
Registration Status: ActiveSIN07055P
ASMALIN SYRUP 1.5mg/5ml is approved to be sold in Singapore with effective from 1992-12-06. It is marketed by SUNWARD PHARMACEUTICAL PTE LTD, with the registration number of SIN07055P.
This product contains Terbutaline 1.5mg/5ml in the form of SYRUP. It is approved for ORAL use.
This product is manufactured by SUNWARD PHARMACEUTICAL PRIVATE LIMITED in SINGAPORE, andSUNWARD PHARMACEUTICAL SDN BHD in MALAYSIA.
It is a Pharmacy Only Medicine that can be obtained from a pharmacist at a retail pharmacy.
Product Reference
Important Note: For generic product, the SPC/PIL provided may not be brand specific.
{{/items}} {{^items}}Description
A selective beta-2 adrenergic agonist used as a bronchodilator and tocolytic. [PubChem]
Indication
For the prevention and reversal of bronchospasm in patients 12 years of age and older with reversible, obstructive airway disease, as well as symptomatic management of reversible bronchospasm associated with bronchitis and emphysema. Also used acute IV and sub-Q therapy in selected women to inhibit uterine contractions in preterm labor (tocolysis) and prolong gestation when beneficial.
Mechanism of Action
The pharmacologic effects of terbutaline are at least in part attributable to stimulation through beta-adrenergic receptors of intracellular adenyl cyclase, the enzyme that catalyzes the conversion of adenosine triphosphate (ATP) to cyclic- 3',5'- adenosine monophosphate (c-AMP). Increased c-AMP levels are associated with relaxation of bronchial smooth muscle and inhibition of release of mediators of immediate hypersensitivity from cells, especially from mast cells.
Pharmacokinetics
- Absorption
- Approximately 30-50% if administered orally and well absorbed subcutaneously.
- Distribution
- Metabolism
- Elimination
Clearance
* 311 +/- 112 mL/min
Toxicity
Terbutaline Sulfate: Oral LD50(rat) = 8.7 g/kg; Oral LD50(mouse) = 205 mg/kg; Oral LD50(dog) = 1.5 g/kg; IP LD50(rat)= 220 mg/kg ; IP LD50(mouse) = 130 mg/kg; Oral LD50(rabbit) = >8 g/kg; IV LD50(mouse) = 36 mg/kg; IV LD50(dog) = 116 mg/kg; IV LD50(rabbit) = 110 mg/kg
Active Ingredient/Synonyms
Terbutalin | Terbutalina | Terbutaline (sulfate de) | Terbutalini sulfas | Terbutalinsulfat | Terbutalinum | Terbutaline |
Source of information: Drugbank (External Link). Last updated on: 3rd July 18. *Trade Name used in the content below may not be the same as the HSA-registered product.