Product Information
Registration Status: ActiveSIN02652P
BUCLIZINE TABLET 25mg is approved to be sold in Singapore with effective from 1989-04-27. It is marketed by BEACONS PHARMACEUTICALS PTE LTD, with the registration number of SIN02652P.
This product contains Buclizine 25mg in the form of TABLET. It is approved for ORAL use.
This product is manufactured by BEACONS PHARMACEUTICALS PTE LTD in SINGAPORE.
It is a Pharmacy Only Medicine that can be obtained from a pharmacist at a retail pharmacy.
Product Reference
Important Note: For generic product, the SPC/PIL provided may not be brand specific.
{{/items}} {{^items}}Description
Buclizine is an antihistamine of the piperazine derivative family.
Indication
For prevention and treatment of nausea, vomiting, and dizziness associated with motion sickness and vertigo (dizziness caused by other medical problems).
Mechanism of Action
Vomiting (emesis) is essentially a protective mechanism for removing irritant or otherwise harmful substances from the upper GI tract. Emesis or vomiting is controlled by the vomiting centre in the medulla region of the brain, an important part of which is the chemotrigger zone (CTZ). The vomiting centre possesses neurons which are rich in muscarinic cholinergic and histamine containing synapses. These types of neurons are especially involved in transmission from the vestibular apparatus to the vomiting centre. Motion sickness principally involves overstimulation of these pathways due to various sensory stimuli. Hence the action of buclizine which acts to block the histamine receptors in the vomiting centre and thus reduce activity along these pathways. Furthermore since buclizine possesses anti-cholinergic properties as well, the muscarinic receptors are similarly blocked.
Pharmacokinetics
- Absorption
- Rapidly absorbed following oral administration.
- Distribution
- Metabolism
- Hepatic.
- Elimination
Active Ingredient/Synonyms
1-(P-Tert-butylbenzyl)-4-(4-chloro-alpha-phenylbenzyl)piperazine | Buclizina | Buclizine | Buclizinum | Buclizine |
Source of information: Drugbank (External Link). Last updated on: 3rd July 18. *Trade Name used in the content below may not be the same as the HSA-registered product.