Product Information

Registration Status: Active

FREEZ-EEZ TOPICAL ANESTHETIC GEL 20% W/W is approved to be sold in Singapore with effective from 2003-08-14. It is marketed by PHARMAFORTE SINGAPORE PTE LTD, with the registration number of SIN12391P.

This product contains Benzocaine 20% w/w in the form of GEL. It is approved for TOPICAL use.

This product is manufactured by GERMIPHENE CORPORATION in CANADA.

It is a Pharmacy Only Medicine that can be obtained from a pharmacist at a retail pharmacy.



A surface anesthetic that acts by preventing transmission of impulses along nerve fibers and at nerve endings. [PubChem]


For general use as a lubricant and topical anesthetic on esophagus, larynx, mouth, nasal cavity, rectum, respiratory tract or trachea, urinary tract, vagina. It is also used to suppress gag reflex.

Mechanism of Action

Benzocaine binds to sodium channels and reversibly stabilizes the neuronal membrane which decreases its permeability to sodium ions. Depolarization of the neuronal membrane is inhibited thereby blocking the initiation and conduction of nerve impulses.


LD50=3040 mg/kg (rat, oral)

Active Ingredient/Synonyms

4-aminobenzoic acid ethyl ester | Amben ethyl ester | Benzocaina | Benzocaine | Benzocainum | Ethyl Aminobenzoate | Ethyl p-Aminobenzoate | Ethyl p-Aminophenylcarboxylate | p-(Ethoxycarbonyl)aniline | p-Carbethoxyaniline | p-Ethoxycarboxylic Aniline | Benzocaine |

Source of information: Drugbank (External Link). Last updated on: 3rd July 18. *Trade Name used in the content below may not be the same as the HSA-registered product.


  1. Health Science Authority of Singapore - Reclassified POM
  2. Drugbank