Product Information
Registration Status: ActiveGYNO-PEVARYL DEPOT VAGINAL SUPPOSITORY 150mg is approved to be sold in Singapore with effective from 1989-05-06. It is marketed by JOHNSON & JOHNSON PTE LTD, with the registration number of SIN03074P.
This product contains Econazole 150mg in the form of SUPPOSITORY. It is approved for VAGINAL use.
This product is manufactured by Xian-Janssen Pharmaceutical Ltd. in PORTUGAL, and in CHINA.
It is a Pharmacy Only Medicine that can be obtained from a pharmacist at a retail pharmacy.
Description
A broad spectrum antimycotic with some action against Gram positive bacteria. It is used topically in dermatomycoses also orally and parenterally. [PubChem]
Indication
For topical application in the treatment of tinea pedis, tinea cruris, and tinea corporis caused by Trichophyton rubrum, Trichophyton mentagrophytes, Trichophyton tonsurans, Microsporum canis, Microsporum audouini, Microsporum gypseum, and Epidermophyton floccosum, in the treatment of cutaneous candidiasis, and in the treatment of tinea versicolor.
Mechanism of Action
Econazole interacts with 14-α demethylase, a cytochrome P-450 enzyme necessary to convert lanosterol to ergosterol. As ergosterol is an essential component of the fungal cell membrane, inhibition of its synthesis results in increased cellular permeability causing leakage of cellular contents. Econazole may also inhibit endogenous respiration, interact with membrane phospholipids, inhibit the transformation of yeasts to mycelial forms, inhibit purine uptake, and impair triglyceride and/or phospholipid biosynthesis.
Pharmacokinetics
- Absorption
- After topical application to the skin of normal subjects, systemic absorption of econazole nitrate is extremely low. Although most of the applied drug remains on the skin surface, drug concentrations were found in the stratum corneum which, by far, exceeded the minimum inhibitory concentration for dermatophytes.
- Distribution
- Metabolism
- Hepatic.
- Elimination
Toxicity
Overdosage of econazole in humans has not been reported to date. In mice, rats guinea pigs and dogs, the oral LD 50 values were found to be 462, 668, 272, and > 160 mg/kg, respectively.
Active Ingredient/Synonyms
(+-)-Econazole | 1-(2,4-Dichloro-beta-((P-chlorobenzyl)oxy)phenethyl)imidazole | Econazole | Econazole Nitrate | Econazole |
Source of information: Drugbank (External Link). Last updated on: 3rd July 18. *Trade Name used in the content below may not be the same as the HSA-registered product.