Product Information
Registration Status: ActiveSIN10845P
MECLOSIL TABLET is approved to be sold in Singapore with effective from 1999-03-25. It is marketed by SUNWARD PHARMACEUTICAL PTE LTD, with the registration number of SIN10845P.
This product contains Aluminium Hydroxide 325mg,Magnesium Carbonate 2.5mg,Dicyclomine 10mg, and Simethicone in the form of TABLET. It is approved for ORAL use.
This product is manufactured by SUNWARD PHARMACEUTICAL PTE LTD in SINGAPORE.
It is a Pharmacy Only Medicine that can be obtained from a pharmacist at a retail pharmacy.
Product Reference
Important Note: For generic product, the SPC/PIL provided may not be brand specific.
{{/items}} {{^items}}Description
Aluminum hydroxide is an inorganic salt used as an antacid. It is a basic compound that acts by neutralizing hydrochloric acid in gastric secretions. Subsequent increases in pH may inhibit the action of pepsin. An increase in bicarbonate ions and prostaglandins may also confer cytoprotective effects.
Indication
For relief of heartburn and acid indigestion.
Mechanism of Action
Aluminum hydroxide is a basic inorganic salt that acts by neutralizing hydrochloric acid in gastric secretions. Aluminum hydroxide is slowly solubilized in the stomach and reacts with hydrochloric acid to form aluminum chloride and water. It also inhibits the action of pepsin by increasing the pH and via adsorption. Cytoprotective effects may occur through increases in bicarbonate ion (HCO3-) and prostaglandins.
Pharmacokinetics
- Absorption
- Approximately 17-30% of the aluminum chloride formed is absorbed.
- Distribution
- Metabolism
- Not metabolized.
- Elimination
Active Ingredient/Synonyms
Aluminium hydroxide | Aluminium hydroxide gel, dried | Aluminium hydroxide, dried | Aluminum hydroxide gel, dried | Aluminum hydroxide, dried | Dried aluminium hydroxide | Dried aluminum hydroxide gel | Aluminum hydroxide |
Source of information: Drugbank (External Link). Last updated on: 3rd July 18. *Trade Name used in the content below may not be the same as the HSA-registered product.
Description
Magnesium carbonate, also known as magnesite, is a common over the counter remedy for heartburn and upset stomach caused by overproduction of acid in the stomach [FDA Label].
Indication
Used as an over the counter antacid [L593].
Mechanism of Action
Magnesium carbonate reacts with hydrochloric acid in the stomach to form carbon dioxide and magnesium chloride thus neutralizing excess acid in the stomach [L593].
Pharmacokinetics
- Absorption
- About 40-60% of magnesium is absorbed following oral administration [L593]. Percent absorption decreases as dose increases.
- Distribution
- Vd for magnesium is 0.2-0.4L/kg [L593]. About 50% distributes to bone.
- Metabolism
- Magnesium does not appear to be metabolized in any way [L593].
- Elimination
Clearance
Maximum magnesium clearance is directly proportional to creatinine clearance [L593].
Toxicity
During overdose, magnesium impairs neuromuscular transmission resulting in weakness and hypoflexia [L593].
Active Ingredient/Synonyms
Magnesium carbonate | Magnesium carbonate |
Source of information: Drugbank (External Link). Last updated on: 3rd July 18. *Trade Name used in the content below may not be the same as the HSA-registered product.
Description
A muscarinic antagonist used as an antispasmodic and in urinary incontinence. It has little effect on glandular secretion or the cardiovascular system. It does have some local anesthetic properties and is used in gastrointestinal, biliary, and urinary tract spasms. [PubChem]
Indication
For the treatment of functional bowel/irritable bowel syndrome including Colicky abdominal pain; diverticulitis
Mechanism of Action
Action is achieved via a dual mechanism: (1) a specific anticholinergic effect (antimuscarinic) at the acetylcholine-receptor sites and (2) a direct effect upon smooth muscle (musculotropic).
Active Ingredient/Synonyms
2-(Diethylamino)ethyl 1-cyclohexylcyclohexanecarboxylate | Bicyclohexyl-1-carboxylic acid 2-diethylamino-ethyl ester | Dicicloverina | DICYCLOMINE | Dicycloverin | Dicycloverine | Dicycloverinum | Dicyclomine |
Source of information: Drugbank (External Link). Last updated on: 3rd July 18. *Trade Name used in the content below may not be the same as the HSA-registered product.
Description
Simethicone is an orally administered antifoaming agent. It is mainly used to reduce gas from the gastrointestinal tract (GIT) in patients complaining from recurrent flatulence. Simethicone is a mixture of polydimethylsiloxane and hydrated silica gel. It exerts its action locally in the GIT, it is not absorbed into the blood stream. The main side effects of simethicone are GIT related including: mild diarrhea, nausea and vomiting.
Indication
1. To relieve pain and discomfort caused by excess gas in the intestine and stomach in cases such as flatulence and post operative gaseous distention. 2. It could be used also prior to an endoscopy to eliminate foam, gas and air from the gastrointestinal tract to reduce gas shadow which will result in better visualization.
Mechanism of Action
Decreases the surface tension of gas bubbles thereby disperses and prevents gas pockets in the GI system.
Pharmacokinetics
- Absorption
- Not absorbed following oral administration.
- Distribution
- Simethicone is pharmacologically inert and is not absorbed from the gastrointestinal tract.
- Metabolism
- The drug is not absorbed and it is excreted in the feces unchanged.
- Elimination
Clearance
Excreted unchanged in feces.
Toxicity
LD50 (oral, rat): 4070 mg/Kg.
Active Ingredient/Synonyms
Simeticone | Simethicone |
Source of information: Drugbank (External Link). Last updated on: 3rd July 18. *Trade Name used in the content below may not be the same as the HSA-registered product.