Product InformationRegistration Status: Active
NAFTATE CREAM 1% W/W is approved to be sold in Singapore with effective from 1990-05-21. It is marketed by SUNWARD PHARMACEUTICAL PTE LTD, with the registration number of SIN04473P.
This product contains Tolnaftate 1% w/w in the form of CREAM. It is approved for TOPICAL use.
This product is manufactured by SUNWARD PHARMACEUTICAL PTE LTD in SINGAPORE.
It is a Pharmacy Only Medicine that can be obtained from a pharmacist at a retail pharmacy.
Tolnaftate is a synthetic over-the-counter anti-fungal agent. It may come as a cream, powder, spray, or liquid aerosol, and is used to treat jock itch, athlete's foot and ringworm. It is sold under several brand names, most notably Tinactin and Odor Eaters.
Tolnaftate topical is used to treat skin infections such as athlete's foot, jock itch, and ringworm infections. Tolnaftate is also used, along with other antifungals, to treat infections of the nails, scalp, palms, and soles of the feet. The powder and powder aerosol may be used to prevent athlete's foot.
Mechanism of Action
Tolnaftate is a topical fungicide. Though its exact mechanism unknown, it is believed to prevent ergosterol biosynthesis by inhibiting squalene epoxidase. It has also been reported to distort the hyphae and to stunt mycelial growth in susceptible organisms.
Oral rat LD50: 891 mg/kg. Inhalation rat LC50: > 900 mg/m3/1hr. Irritation: skin rabbit: 500 mg/24H mild. Eye rabbit: 100 mg severe. Investigated a mutagen and reproductive effector.
2-Naphthyl N-methyl-N-(3-tolyl)thionocarbamate | m,N-Dimethylthiocarbanilic acid O-2-naphthyl ester | Methyl (3-methylphenyl)carbamothioic acid O-2-naphthalenyl ester | N-Methyl-N-(3-methylphenyl)-1-(naphthalen-2-yloxy)methanethioamide | O-2-Naphthyl m,N-dimethylthiocarbanilate | Separin | Tolnaftato | Tolnaftatum | Tolnaphthate | Tolnaftate |
Source of information: Drugbank (External Link). Last updated on: 3rd July 18. *Trade Name used in the content below may not be the same as the HSA-registered product.