Product Information
Registration Status: ActivePHOSPHO-SODA ORAL SOLUTION is approved to be sold in Singapore with effective from 2003-03-17. It is marketed by EURO ASIA MEDICO PTE LTD, with the registration number of SIN12230P.
This product contains Sodium Phosphate 0.9g/5ml in the form of SOLUTION. It is approved for ORAL use.
This product is manufactured by Casen Recordati S.L. in SPAIN.
It is a Pharmacy Only Medicine that can be obtained from a pharmacist at a retail pharmacy.
Description
Sodium phosphate is a saline laxative that is thought to work by increasing fluid in the small intestine. It usually results in a bowel movement after 30 minutes to 6 hours.
Indication
Used to treat constipation or to clean the bowel before a colonoscopy [FDA Label].
Mechanism of Action
Sodium phosphate is thought to work by increasing the amount of solute present in the intestinal lumen thereby creating an osmotic gradient which draws water into the lumen [A19446].
Pharmacokinetics
- Absorption
- Tmax for phosphate absorption with orally administered liquid sodium phosphate is 1-3h [A19448].
- Distribution
- Metabolism
- Elimination
Toxicity
Intamuscular LD50 of 250mg/kg and oral LD50 of 8290 mg/kg reported in rats [L799]. Phosphate toxicity is likely due to the disturbance of other electrolytes when phosphate levels are high, producing symptoms including tetany, dehydration, hypotension, tachycardia, hyperpyrexia, cardiac arrest and coma [A19449]. Risk of raising phosphate levels through use of sodium phosphate appears to be higher in smaller patients [A19448].
Active Ingredient/Synonyms
Sodium orthophosphate | Sodium phosphate monobasic | Sodium phosphate monobasic (anhydrate) | Sodium phosphate, unspecified | Sodium phosphates | Sodium phosphate |
Source of information: Drugbank (External Link). Last updated on: 3rd July 18. *Trade Name used in the content below may not be the same as the HSA-registered product.