Product Information
Registration Status: ActivePILIAN TABLET 4mg is approved to be sold in Singapore with effective from 1991-10-22. It is marketed by YUNG SHIN PHARMACEUTICAL (SINGAPORE) PTE LTD, with the registration number of SIN06637P.
This product contains Cyproheptadine 4mg in the form of TABLET. It is approved for ORAL use.
This product is manufactured by YUNG SHIN PHARMACEUTICAL IND CO LTD in TAIWAN.
It is a Pharmacy Only Medicine that can be obtained from a pharmacist at a retail pharmacy.
Description
A serotonin antagonist and a histamine H1 blocker used as antipruritic, appetite stimulant, antiallergic, and for the post-gastrectomy dumping syndrome, etc. [PubChem]
Indication
For treatment of perennial and seasonal allergic rhinitis, vasomotor rhinitis, allergic conjunctivitis due to inhalant allergens and foods, mild uncomplicated allergic skin manifestations of urticaria and angioedema, amelioration of allergic reactions to blood or plasma, cold urticaria, dermatographism, and as therapy for anaphylactic reactions adjunctive to epinephrine.
Mechanism of Action
Cyproheptadine competes with free histamine for binding at HA-receptor sites. This antagonizes the effects of histamine on HA-receptors, leading to a reduction of the negative symptoms brought on by histamine HA-receptor binding. Cyproheptadine also competes with serotonin at receptor sites in smooth muscle in the intestines and other locations. Antagonism of serotonin on the appetite center of the hypothalamus may account for Cyproheptadine's ability to stimulate appetite.
Pharmacokinetics
- Absorption
- Well absorbed after oral administration.
- Distribution
- Metabolism
- Hepatic (cytochrome P-450 system) and some renal.
- Elimination
Active Ingredient/Synonyms
1-methyl-4-(5-dibenzo(a,e)cycloheptatrienylidene)piperidine | 1-Methyl-4-(5H-dibenzo(a,d)cycloheptenylidene)piperidine | 4-(5-Dibenzo(a,D)cyclohepten-5-ylidine)-1-methylpiperidine | 4-(5H-Dibenzo(a,D)cyclohepten-5-ylidene)-1-methylpiperidine | 4-Dibenzo[a,D]cyclohepten-5-ylidene-1-methyl-piperidine | 5-(1-methylpiperidylidene-4)-5H-dibenzo(a,d)cyclopheptene | Axoprol | Ciproheptadina | Cyproheptadin | Cyproheptadine | Cyproheptadinum | Dihexazin | Glutodina | Cyproheptadine |
Source of information: Drugbank (External Link). Last updated on: 3rd July 18. *Trade Name used in the content below may not be the same as the HSA-registered product.