Product Information
Registration Status: ActiveSIN09449P
POLI-FLUNARIN CAPSULE 5mg is approved to be sold in Singapore with effective from 1997-07-23. It is marketed by MD PHARMACEUTICALS PTE LTD, with the registration number of SIN09449P.
This product contains Flunarizine 5mg in the form of CAPSULE. It is approved for ORAL use.
This product is manufactured by POLIPHARM CO LTD in THAILAND.
It is a Pharmacy Only Medicine that can be obtained from a pharmacist at a retail pharmacy.
Product Reference
Important Note: For generic product, the SPC/PIL provided may not be brand specific.
{{/items}} {{^items}}Description
Flunarizine is a selective calcium entry blocker with calmodulin binding properties and histamine H1 blocking activity. It is effective in the prophylaxis of migraine, occlusive peripheral vascular disease, vertigo of central and peripheral origin, and as an adjuvant in the therapy of epilepsy.
Indication
Used in the prophylaxis of migraine, occlusive peripheral vascular disease, vertigo of central and peripheral origin, and as an adjuvant in the therapy of epilepsy.
Mechanism of Action
Flunarizine inhibits the influx of extracellular calcium through myocardial and vascular membrane pores by physically plugging the channel. The decrease in intracellular calcium inhibits the contractile processes of smooth muscle cells, causing dilation of the coronary and systemic arteries, increased oxygen delivery to the myocardial tissue, decreased total peripheral resistance, decreased systemic blood pressure, and decreased afterload.
Pharmacokinetics
- Absorption
- 85% following oral administration.
- Distribution
- Metabolism
- Hepatic, to two metabolites via N-dealylation and hydroxylation.
- Elimination
Toxicity
#NAME?
Active Ingredient/Synonyms
1-[bis(4-fluorophenyl)methyl]-4-[(2E)-3-phenylprop-2-en-1-yl]piperazine | Flunarizina | Flunarizinum | Flunarizine |
Source of information: Drugbank (External Link). Last updated on: 3rd July 18. *Trade Name used in the content below may not be the same as the HSA-registered product.