Product Information
Registration Status: ActivePROCANOL LOTION 2% is approved to be sold in Singapore with effective from 1997-01-25. It is marketed by ICM PHARMA PTE LTD, with the registration number of SIN09166P.
This product contains Procaine 2% in the form of LOTION. It is approved for TOPICAL use.
This product is manufactured by ICM PHARMA PTE LTD in SINGAPORE.
It is a Pharmacy Only Medicine that can be obtained from a pharmacist at a retail pharmacy.
Description
A local anesthetic of the ester type that has a slow onset and a short duration of action. It is mainly used for infiltration anesthesia, peripheral nerve block, and spinal block. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1016). Procaine has also been investigated as an oral entry inhibitor in treatment-experienced HIV patients [L1215].
Indication
Used as a local anesthetic primarily in oral surgery
Mechanism of Action
Procaine acts mainly by inhibiting sodium influx through voltage gated sodium channels in the neuronal cell membrane of peripheral nerves. When the influx of sodium is interrupted, an action potential cannot arise and signal conduction is thus inhibited. The receptor site is thought to be located at the cytoplasmic (inner) portion of the sodium channel. Procaine has also been shown to bind or antagonize the function of N-methyl-D-aspartate (NMDA) receptors as well as nicotinic acetylcholine receptors and the serotonin receptor-ion channel complex.
Active Ingredient/Synonyms
2-Diethylaminoethyl p-aminobenzoate | 4-aminobenzoic acid 2-diethylaminoethyl ester | Novocaine | p-Aminobenzoic acid 2-diethylaminoethyl ester | Procaina | Procainum | Vitamin H3 | β-(diethylamino)ethyl 4-aminobenzoate | β-(diethylamino)ethyl p-aminobenzoate | Procaine |
Source of information: Drugbank (External Link). Last updated on: 3rd July 18. *Trade Name used in the content below may not be the same as the HSA-registered product.