Product InformationRegistration Status: Active
RESOLVE THRUSH CREAM 2% W/W is approved to be sold in Singapore with effective from 1998-03-10. It is marketed by EGO PHARMACEUTICALS (SINGAPORE) PTE LTD, with the registration number of SIN10181P.
This product contains Miconazole 2% w/w in the form of CREAM. It is approved for TOPICAL use.
This product is manufactured by EGO PHARMACEUTICALS PTY LTD in AUSTRALIA.
It is a Pharmacy Only Medicine that can be obtained from a pharmacist at a retail pharmacy.
An imidazole antifungal agent that is used topically and by intravenous infusion. [PubChem]
For topical application in the treatment of tinea pedis (athlete’s foot), tinea cruris, and tinea corporis caused by Trichophyton rubrum, Trichophyton mentagrophytes, and Epidermophyton floccosum, in the treatment of cutaneous candidiasis (moniliasis), and in the treatment of tinea versicolor.
Mechanism of Action
Miconazole interacts with 14-α demethylase, a cytochrome P-450 enzyme necessary to convert lanosterol to ergosterol. As ergosterol is an essential component of the fungal cell membrane, inhibition of its synthesis results in increased cellular permeability causing leakage of cellular contents. Miconazole may also inhibit endogenous respiration, interact with membrane phospholipids, inhibit the transformation of yeasts to mycelial forms, inhibit purine uptake, and impair triglyceride and/or phospholipid biosynthesis.
Oral, mouse: LD50 = 3800 mg/kg; Oral, rat: LD50 = 3 gm/kg. Ingestion of the amounts of the components contained in a tube of cream are unlikely to produce overdosage and toxic effects.
1-(2,4-Dichloro-beta-((2,4-dichlorobenzyl)oxy)phenethyl)imidazole | 1-[2-(2,4-Dichloro-benzyloxy)-2-(2,4-dichloro-phenyl)-ethyl]-1H-imidazole | Daktarin iv | Miconazole | Monistat iv (tn) | Miconazole |
Source of information: Drugbank (External Link). Last updated on: 3rd July 18. *Trade Name used in the content below may not be the same as the HSA-registered product.