Product InformationRegistration Status: Active
RINITYN TABLET 10mg is approved to be sold in Singapore with effective from 2002-12-09. It is marketed by GOLDPLUS UNIVERSAL PTE LTD, with the registration number of SIN12067P.
This product contains Loratadine 10mg in the form of TABLET. It is approved for ORAL use.
This product is manufactured by HOVID BHD HOVID Bhd. in MALAYSIA.
It is a Pharmacy Only Medicine that can be obtained from a pharmacist at a retail pharmacy.
Loratadine is a derivative of azatadine and a second-generation histamine H1 receptor antagonist used in the treatment of allergic rhinitis and urticaria. Unlike most classical antihistamines (histamine H1 antagonists) it lacks central nervous system depressing effects such as drowsiness. [PubChem]
A self-medication that is used alone or in combination with pseudoephedrine sulfate for the symptomatic relief of seasonal allergic rhinitis. Also used for the symptomatic relief of pruritus, erythema, and urticaria associated with chronic idiopathic urticaria in patients (not for children under 6 unless directed by a clincian).
Mechanism of Action
Loratadine competes with free histamine and exhibits specific, selective peripheral H1 antagonistic activity. This blocks the action of endogenous histamine, which subsequently leads to temporary relief of the negative symptoms (eg. nasal congestion, watery eyes) brought on by histamine. Loratadine has low affinity for cholinergic receptors and does not exhibit any appreciable alpha-adrenergic blocking activity in-vitro. Loratadine also appears to suppress the release of histamine and leukotrienes from animal mast cells, and the release of leukotrienes from human lung fragments, although the clinical importance of this is unknown.
- Rapidly absorbed following oral administration (40% bioavailability)
somnolence, tachycardia, and headache LD50=mg/kg (orally in rat)
Loratadina | Loratadinum | Loratadine |
Source of information: Drugbank (External Link). Last updated on: 3rd July 18. *Trade Name used in the content below may not be the same as the HSA-registered product.