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ROSIDEN GEL

Product Information

Registration Status: Active

SIN05100P

ROSIDEN GEL is approved to be sold in Singapore with effective from 1990-03-10. It is marketed by ZYFAS MEDICAL CO, with the registration number of SIN05100P.

This product contains Piroxicam 5mg/g in the form of GEL. It is approved for TOPICAL use.

This product is manufactured by SHIN POONG PHARMACEUTICAL CO LTD in KOREA, and in REPUBLIC OF.

It is a Pharmacy Only Medicine that can be obtained from a pharmacist at a retail pharmacy.

Product Reference
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Description

A cyclooxygenase inhibiting, non-steroidal anti-inflammatory agent (NSAID) that is well established in treating rheumatoid arthritis and osteoarthritis and used for musculoskeletal disorders, dysmenorrhea, and postoperative pain. Its long half-life enables it to be administered once daily. [PubChem]

Indication

For treatment of osteoarthritis and rheumatoid arthritis.

Mechanism of Action

The antiinflammatory effect of Piroxicam may result from the reversible inhibition of cyclooxygenase, causing the peripheral inhibition of prostaglandin synthesis. The prostaglandins are produced by an enzyme called Cox-1. Piroxicam blocks the Cox-1 enzyme, resulting into the disruption of production of prostaglandins. Piroxicam also inhibits the migration of leukocytes into sites of inflammation and prevents the formation of thromboxane A2, an aggregating agent, by the platelets.

Pharmacokinetics

Absorption
Well absorbed following oral administration.
Distribution
* 0.14 L/kg
Metabolism
Renal
Elimination

Toxicity

Symptoms of overdose include drowsiness, nausea, stomach pain, and/or vomiting.

Active Ingredient/Synonyms

4-Hydroxy-2-methyl-N-(2-pyridyl)-2H-1,2-benzothiazin-3-caboxyamid-1,1-dioxid | Piroxicam | Piroxicam betadex | Piroxicamum | Pyroxycam | Piroxicam |


Source of information: Drugbank (External Link). Last updated on: 3rd July 18. *Trade Name used in the content below may not be the same as the HSA-registered product.

References

  1. Health Science Authority of Singapore - Reclassified POM
  2. Drugbank

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