Product InformationRegistration Status: Active
TROSYD DERMAL CREAM 1% is approved to be sold in Singapore with effective from 1990-04-30. It is marketed by PFIZER PTE LTD, with the registration number of SIN04265P.
This product contains Tioconazole 1.0g in the form of CREAM. It is approved for TOPICAL use.
This product is manufactured by FAMAR S.A. in GREECE.
It is a Pharmacy Only Medicine that can be obtained from a pharmacist at a retail pharmacy.
Tioconazole is an antifungal medication of the Imidazole class used to treat infections caused by a fungus or yeast. Tioconazole topical (skin) preparations are also available for ringworm, jock itch, athlete's foot, and tinea versicolor or "sun fungus". Tioconazole interacts with 14-alpha demethylase, a cytochrome P-450 enzyme that converts lanosterol to ergosterol, an essential component of the yeast membrane. In this way, tioconazole inhibits ergosterol synthesis, resulting in increased cellular permeability.
For the local treatment of vulvovaginal candidiasis (moniliasis).
Mechanism of Action
Tioconazole interacts with 14-α demethylase, a cytochrome P-450 enzyme that converts lanosterol to ergosterol, an essential component of the yeast membrane. In this way, tioconazole inhibits ergosterol synthesis, resulting in increased cellular permeability. Tioconazole may also inhibit endogenous respiration, interact with membrane phospholipids, inhibit the transformation of yeasts to mycelial forms and the uptake of purine, impair triglyceride and/or phospholipid biosynthesis, and inhibit the movement of calcium and potassium ions across the cell membrane by blocking the ion transport pathway known as the Gardos channel.
- Systemic absorption following a single intravaginal application of tioconazole in nonpregnant patients is negligible.
- Orally administered tioconazole is extensively metabolized. The major metabolites are glucuronide conjugates.
Symptoms of overdose include erythema, stinging, blistering, peeling, edema, pruritus, urticaria, burning, and general irritation of the skin, and cramps.
Tioconazol | Tioconazolum | Tioconazole |
Source of information: Drugbank (External Link). Last updated on: 3rd July 18. *Trade Name used in the content below may not be the same as the HSA-registered product.