Product Information
Registration Status: ActiveTUSSILS 5 LOZENGE 5mg is approved to be sold in Singapore with effective from 1996-05-08. It is marketed by RECKITT BENCKISER (SINGAPORE) PTE LTD, with the registration number of SIN08825P.
This product contains Dextromethorphan 5mg in the form of LOZENGE. It is approved for ORAL use.
This product is manufactured by RECKITT BENCKISER HEALTHCARE MANUFACTURING (THAILAND) LTD in THAILAND.
It is a Pharmacy Only Medicine that can be obtained from a pharmacist at a retail pharmacy.
Description
The d-isomer of the codeine analog of levorphanol. Dextromethorphan shows high affinity binding to several regions of the brain, including the medullary cough center. This compound is an NMDA receptor antagonist (receptors, N-methyl-D-aspartate) and acts as a non-competitive channel blocker. It is one of the widely used antitussives, and is also used to study the involvement of glutamate receptors in neurotoxicity. [PubChem]
Indication
For treatment and relief of dry cough.
Mechanism of Action
Dextromethorphan is an opioid-like drug that binds to and acts as antagonist to the NMDA glutamatergic receptor, it is an agonist to the opioid sigma 1 and sigma 2 receptors, it is also an alpha3/beta4 nicotinic receptor antagonist and targets the serotonin reuptake pump. Dextromethorphan is rapidly absorbed from the gastrointestinal tract, where it enters the bloodstream and crosses the blood-brain barrier. The first-pass through the hepatic portal vein results in some of the drug being metabolized into an active metabolite of dextromethorphan, dextrorphan, the 3-hydroxy derivative of dextromethorphan.
Pharmacokinetics
- Absorption
- Rapidly absorbed from the gastrointestinal tract.
- Distribution
- Metabolism
- Hepatic. Rapidly and extensively metabolized to dextrorphan (active metabolite). One well known metabolic catalyst involved is a specific cytochrome P450 enzyme known as 2D6, or CYP2D6.
- Elimination
Active Ingredient/Synonyms
(+)-dextromethorphan | D-methorphan | delta-Methorphan | Dex | Dextromethorfan | Dextromethorphan | Dextrométhorphane | Dextromethorphanum | Dextrometorfano | DM | Dextromethorphan |
Source of information: Drugbank (External Link). Last updated on: 3rd July 18. *Trade Name used in the content below may not be the same as the HSA-registered product.