Product Information
Registration Status: ActiveVACONTIL CAPSULE 2mg is approved to be sold in Singapore with effective from 1991-03-27. It is marketed by MEDOCHEMIE SINGAPORE PTE LTD, with the registration number of SIN05587P.
This product contains Loperamide 2mg in the form of CAPSULE. It is approved for ORAL use.
This product is manufactured by MEDOCHEMIE LTD in CYPRUS.
It is a Pharmacy Only Medicine that can be obtained from a pharmacist at a retail pharmacy.
Description
One of the long-acting synthetic antidiarrheals; it is not significantly absorbed from the gut, and has no effect on the adrenergic system or central nervous system, but may antagonize histamine and interfere with acetylcholine release locally. [PubChem]
Indication
For the control and symptomatic relief of acute nonspecific diarrhea and of chronic diarrhea associated with inflammatory bowel disease or gastroenteritis. Also used for reducing the volume of discharge from ileostomies.
Mechanism of Action
In vitro and animal studies show that Loperamide acts by slowing intestinal motility and by affecting water and electrolyte movement through the bowel. Loperamide inhibits peristaltic activity by a direct effect on the circular and longitudinal muscles of the intestinal wall. It is a non-selective calcium channel blocker and binds to opioid mu-receptors. Evidence also suggests that at higher concentrations it binds to calmodulin.
Pharmacokinetics
- Absorption
- Not significantly absorbed from the gut
- Distribution
- Metabolism
- Hepatic
- Elimination
Toxicity
Oral, mouse: LD50 = 105 mg/kg. Symptoms of overdose include constipation, drowsiness, lethargy, and nausea.
Active Ingredient/Synonyms
Loperamid | Loperamida | Lopéramide | Loperamidum | Loperamide |
Source of information: Drugbank (External Link). Last updated on: 3rd July 18. *Trade Name used in the content below may not be the same as the HSA-registered product.