Product Information
Registration Status: ActiveZALAIN CREAM 2% is approved to be sold in Singapore with effective from 1999-05-17. It is marketed by DCH AURIGA SINGAPORE, with the registration number of SIN10933P.
This product contains Sertaconazole 2% in the form of CREAM. It is approved for TOPICAL use.
This product is manufactured by FERRER INTERNACIONAL SA in SPAIN.
It is a Pharmacy Only Medicine that can be obtained from a pharmacist at a retail pharmacy.
Description
Sertaconazole nitrate is an antifungal medication of the imidazole class. It is available as a cream to treat skin infections such as athlete's foot.
Indication
For the topical treatment of interdigital tinea pedis in immunocompetent patients 12 years of age and older, caused by Trichophyton rubrum, Trichophyton mentagrophytes, and Epidermophyton floccosum.
Mechanism of Action
Sertaconazole interacts with 14-α demethylase, a cytochrome P-450 enzyme necessary to convert lanosterol to ergosterol. As ergosterol is an essential component of the fungal cell membrane, inhibition of its synthesis results in increased cellular permeability causing leakage of cellular contents. Sertaconazole may also inhibit endogenous respiration, interact with membrane phospholipids, inhibit the transformation of yeasts to mycelial forms, inhibit purine uptake, and impair triglyceride and/or phospholipid biosynthesis.
Pharmacokinetics
- Absorption
- Bioavailability is negligible.
- Distribution
- Metabolism
- Elimination
Active Ingredient/Synonyms
Demofix | Sertaconazol | Sertaconazole | Sertaconazolum | Sertaconazole |
Source of information: Drugbank (External Link). Last updated on: 3rd July 18. *Trade Name used in the content below may not be the same as the HSA-registered product.