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ZALAIN VAGINAL SUPPOSITORY 300mg

Product Information

Registration Status: Active

SIN11905P

ZALAIN VAGINAL SUPPOSITORY 300mg is approved to be sold in Singapore with effective from 2002-04-29. It is marketed by DCH AURIGA SINGAPORE, with the registration number of SIN11905P.

This product contains Sertaconazole 300mg in the form of SUPPOSITORY. It is approved for VAGINAL use.

This product is manufactured by Trommsdorff GmbH & Co in GERMANY.

It is a Pharmacy Only Medicine that can be obtained from a pharmacist at a retail pharmacy.

Product Reference
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Description

Sertaconazole nitrate is an antifungal medication of the imidazole class. It is available as a cream to treat skin infections such as athlete's foot.

Indication

For the topical treatment of interdigital tinea pedis in immunocompetent patients 12 years of age and older, caused by Trichophyton rubrum, Trichophyton mentagrophytes, and Epidermophyton floccosum.

Mechanism of Action

Sertaconazole interacts with 14-α demethylase, a cytochrome P-450 enzyme necessary to convert lanosterol to ergosterol. As ergosterol is an essential component of the fungal cell membrane, inhibition of its synthesis results in increased cellular permeability causing leakage of cellular contents. Sertaconazole may also inhibit endogenous respiration, interact with membrane phospholipids, inhibit the transformation of yeasts to mycelial forms, inhibit purine uptake, and impair triglyceride and/or phospholipid biosynthesis.

Pharmacokinetics

Absorption
Bioavailability is negligible.
Distribution
Metabolism
Elimination

Active Ingredient/Synonyms

Demofix | Sertaconazol | Sertaconazole | Sertaconazolum | Sertaconazole |


Source of information: Drugbank (External Link). Last updated on: 3rd July 18. *Trade Name used in the content below may not be the same as the HSA-registered product.

References

  1. Health Science Authority of Singapore - Reclassified POM
  2. Drugbank

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