Product InformationRegistration Status: Active
ZYRTEC TABLET 10mg is approved to be sold in Singapore with effective from 1989-03-06. It is marketed by GLAXOSMITHKLINE PTE LTD, with the registration number of SIN03022P.
This product contains Cetirizine 10mg in the form of TABLET, FILM-COATED. It is approved for ORAL use.
This product is manufactured by UCB FARCHIM S A in SWITZERLAND, andAESICA PHARMACEUTICALS S.R.L (PRIMARY AND SECONDARY PACKAGING) in ITALY.
It is a Pharmacy Only Medicine that can be obtained from a pharmacist at a retail pharmacy.
A potent second-generation histamine H1 antagonist that is effective in the treatment of allergic rhinitis, chronic urticaria, and pollen-induced asthma. Unlike many traditional antihistamines, it does not cause drowsiness or anticholinergic side effects. [PubChem]
For the relief of symptoms associated with seasonal allergic rhinitis, perennial allergic rhinitis and the treatment of the uncomplicated skin manifestations of chronic idiopathic urticaria
Mechanism of Action
Cetirizine competes with histamine for binding at H1-receptor sites on the effector cell surface, resulting in suppression of histaminic edema, flare, and pruritus. The low incidence of sedation can be attributed to reduced penetration of cetirizine into the CNS as a result of the less lipophilic carboxyl group on the ethylamine side chain.
- mean peak plasma concentration (Cmax) of 114 ng/mL at a time (Tmax) of 2.2 hours postdose was observed for cetirizine
* 53 mL/min [healthy]
Somnolence (sleepiness or unusual drowsiness), restlessness, irritability
Cetirizin | Cetirizina | Cetirizinum | Cetirizine |
Source of information: Drugbank (External Link). Last updated on: 3rd July 18. *Trade Name used in the content below may not be the same as the HSA-registered product.