AMGEVITA SOLUTION FOR INJECTION IN PREFILLED SYRINGE 20 mg/0.4 ml

Product Information

Registration Status: Active

AMGEVITA SOLUTION FOR INJECTION IN PREFILLED SYRINGE 20 mg/0.4 ml is approved to be sold in Singapore with effective from 2019-07-02. It is marketed by AMGEN BIOTECHNOLOGY SINGAPORE PTE LTD, with the registration number of SIN15732P.

This product contains Adalimumab 20 mg/0.4 ml in the form of INJECTION, SOLUTION. It is approved for SUBCUTANEOUS use.

This product is manufactured by Amgen Manufacturing Limited in UNITED STATES.

It is a Prescription Only Medicine that can only be obtained from a doctor or a dentist, or a pharmacist with a prescription from a Singapore-registered doctor or dentist.

Adalimumab

Description

Adalimumab is a human monoclonal antibody against TNF-alpha. It is produced by recombinant DNA technology using a mammalian cell expression system. It consists of 1330 amino acids and has a molecular weight of approximately 148 kilodaltons [L1306].

Indication

For treatment of rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, and Crohn's disease.

Mechanism of Action

Adalimumab binds to TNF-alpha and blocks its interaction with the p55 and p75 cell surface TNF receptors. Adalimumab also lyses surface TNF expressing cells in vitro in the presence of complement.

Clearance

* 12 mL/hr [RA patients with dose 0.25-10 mg/kg]

Active Ingredient/Synonyms

Adalimumab (genetical recombination) | adalimumab-adbm | adalimumab-atto | Adalimumab |


Source of information: Drugbank (External Link). Last updated on: 3rd July 18. *Trade Name used in the content below may not be the same as the HSA-registered product.

References

  1. Health Science Authority of Singapore - Reclassified POM
  2. Drugbank