Product Information
Registration Status: InactiveSIN04639P
THIS PRODUCT HAS BEEN DEREGISTERED!
ANDROCUR TABLET 50mg is approved to be sold in Singapore with effective from 1990-06-13. It is marketed by BAYER (SOUTH EAST ASIA) PTE LTD, with the registration number of SIN04639P.
This product contains Cyproterone 50mg in the form of TABLET. It is approved for ORAL use.
This product is manufactured by DELPHARM LILLE S.A.S in FRANCE, andBayer Weimar GmbH und Co. KG in GERMANY.
It is a Prescription Only Medicine that can only be obtained from a doctor or a dentist, or a pharmacist with a prescription from a Singapore-registered doctor or dentist.
Product Reference
Important Note: For generic product, the SPC/PIL provided may not be brand specific.
{{/items}} {{^items}}Description
An anti-androgen that, in the form of its acetate (cyproterone acetate), also has progestational properties. It is used in the treatment of hypersexuality in males, as a palliative in prostatic carcinoma, and, in combination with estrogen, for the therapy of severe acne and hirsutism in females. [Pubchem]
Indication
For the palliative treatment of patients with advanced prostatic carcinoma.
Mechanism of Action
The direct antiandrogenic effect of cyproterone is blockage of the binding of dihydrotestosterone to the specific receptors in the prostatic carcinoma cell. In addition, cyproterone exerts a negative feed-back on the hypothalamo-pituitary axis, by inhibiting the secretion of luteinizing hormone resulting in diminished production of testicular testosterone.
Pharmacokinetics
- Absorption
- Completely absorbed following oral administration.
- Distribution
- Metabolism
- Primarily hepatic. Cyproterone acetate is metabolized by the CYP3A4 enzyme, forming the active metabolite 15beta-hydroxycyproterone acetate, which retains its antiandrogen activity, but has reduced progestational activity.
- Elimination
Active Ingredient/Synonyms
Cyproterone 17-O-acetate | Cyproterone acetate |
Source of information: Drugbank (External Link). Last updated on: 3rd July 18. *Trade Name used in the content below may not be the same as the HSA-registered product.